Document Detail

Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung.
MedLine Citation:
PMID:  11510007     Owner:  NLM     Status:  MEDLINE    
We report a unique case of a combined pulmonary large-cell neuroendocrine carcinoma and spindle-cell carcinoma. The patient was a 54-year-old female smoker who presented with a 4-month history of increased left-sided chest pain and exertional dyspnea. The left upper lobectomy specimen revealed an 8.0-cm mass with central necrosis. Microscopically, the epithelial areas were composed of well-defined nests of large cells with peripheral palisading expressing low-molecular-weight keratin, synaptophysin, chromogranin, and neuron-specific enolase. The spindle-cell component consisted of pleomorphic cells arranged in fibrosarcoma and malignant fibrous histiocytoma-like patterns. These spindle cells were positive for low-molecular-weight keratin and vimentin with focal expression of CD68 and muscle-specific actin. Electron microscopy in the spindle-cell areas showed cell junctions and numerous tonofilaments, indicative of epithelial differentiation. The tumor behaved aggressively and the patient died with extensive metastases 4 months after surgery. The combination of neuroendocrine malignancies and spindle-cell carcinomas appears to be uncommon in the lung. Previous reports have described this association in single case reports of anaplastic small-cell carcinoma and atypical carcinoid, but not in large-cell neuroendocrine carcinoma.
M Khalifa; G Hruby; L Ehrlich; C Danjoux; B Perez-Ordoñez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  5     ISSN:  1092-9134     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
Department of Anatomic Pathology, Sunnybrook and Women's College Health Science Centre, Toronto, Ontario, Canada.
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MeSH Terms
Biopsy, Needle
Carcinoma / pathology*,  ultrastructure
Carcinoma, Large Cell / pathology*,  ultrastructure
Lung / pathology*,  ultrastructure
Lung Neoplasms / pathology*,  ultrastructure
Microscopy, Electron
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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