Document Detail


Combined intraarterial and intravenous thrombolysis for severe cerebral venous sinus thrombosis.
MedLine Citation:
PMID:  19685009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the safety and efficacy of endovascular therapy with combined intra-arterial and intravenous thrombolysis for severe cerebral venous sinus thrombosis. Of the 28 consecutive patients with cerebral venous sinus thrombosis admitted to our hospital in recent 3 years, six patients underwent combined intra-arterial and intravenous thrombolysis. For each patient, local contact thrombolysis was performed with balloon catheter to break clot and urokinase infused for thrombolysis in sinus. At the same time, urokinase (100,000 IU/h) was infused intra-arterially via internal carotid artery to dissolve the venous thrombi. Neurologic outcomes, Glasgow coma scale (GCS), neuroimaging results and modified Rankin Scale score (mRS) were recorded. Of the six treated patients, two were males and four females. Their mean age was 38 +/- 13 (range from 22 to 57) years. Completely recanalization was observed in five patients, whose clinical symptoms recovered completely (mRS score 0). One patient in whom thrombolysis was delayed died the day after the procedure. Endovascular treatment with combined intra-arterial and intravenous thrombolysis may improve neurological outcomes of severe cerebral venous sinus thrombosis.
Authors:
Xuanye Yue; Gangming Xi; Zhiming Zhou; Gelin Xu; Xinfeng Liu
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  29     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, 210002, Nanjing, Jiangsu Province, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Balloon Dilatation / methods
Combined Modality Therapy
Female
Fibrinolytic Agents / administration & dosage*
Humans
Infusions, Intra-Arterial
Infusions, Intravenous
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Sinus Thrombosis, Intracranial / drug therapy*,  radiography*,  therapy
Urokinase-Type Plasminogen Activator / administration & dosage
Young Adult
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

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