Document Detail

Combined intervention of exercise and genistein prevented androgen deficiency-induced bone loss in mice.
MedLine Citation:
PMID:  12486023     Owner:  NLM     Status:  MEDLINE    
There is evidence that estrogen plays an important role in skeletal tissue in males as well as females. We have reported that phytoestrogens, such as genistein, selectively act on bone and exhibit cooperative effects on bone mass when combined with exercise in ovariectomized mice. In this study, we examined whether both interventions exhibit cooperative effects on bone loss in androgen-deficient mice similar to those in estrogen-deficient mice. Male mice aged 7 wk were either sham operated or orchidectomized (ORX) and divided into six groups: 1) sham; 2) ORX; 3) ORX and treated with genistein (0.4 mg/day) subcutaneously; 4) ORX, exercised on a treadmill daily for 30 min/day at 12 m/min; 5) ORX, given genistein, and exercised (ORX+ExG); and 6) ORX and treated with 17beta-estradiol (E(2)). Four weeks after the intervention, seminal vesicle weight strikingly decreased in ORX mice, and it was not affected by administration of genistein or E(2). Bone mineral density of whole femur was significantly reduced by ORX, and bone loss was prevented by the combined intervention. Histomorphometric analysis showed that bone volume and trabecular thickness in the distal femoral cancellous bone were significantly lower in the ORX group than in the Sham group, and they were completely restored in the ORX+ExG group, as in the ORX with E(2) group. These results indicate that the combined intervention of moderate exercise and a low dose of genistein administration shows an additive effect in preventing bone loss in ORX mice similar to that in ovariectomized mice.
Jian Wu; Xin Xiang Wang; Hiroshige Chiba; Mitsuru Higuchi; Misao Takasaki; Atsutane Ohta; Yoshiko Ishimi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-17     Completed Date:  2003-06-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-42     Citation Subset:  IM    
Division of Food Science, National Institute of Health and Nutrition, Tokyo 162 - 8636, Japan.
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MeSH Terms
Androgens / deficiency*
Bone Density / drug effects
Estradiol / pharmacology
Femur / metabolism
Genistein / pharmacology*
Metabolism, Inborn Errors / complications
Mice, Inbred Strains
Motor Activity / physiology*
Organ Size / drug effects
Osteoporosis / etiology*,  prevention & control*
Seminal Vesicles / anatomy & histology,  drug effects
Reg. No./Substance:
0/Androgens; 446-72-0/Genistein; 50-28-2/Estradiol

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