Document Detail

Combined impact of pH and organic acids on iron uptake by Caco-2 cells.
MedLine Citation:
PMID:  14664552     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that organic acids have an impact on both Fe(II) and Fe(III) uptake in Caco-2 cell. However, to what extent this effect is correlated with the anion of organic acids per se, or with the resulting decrease in pH, has not yet been clarified. Therefore, we studied the effect of five organic acids (tartaric, succinic, citric, oxalic, and propionic acid) on the absorption of Fe(II) and Fe(III) in Caco-2 cells and compared this with sample solutions without organic acids but set to equivalent pH by HCl. The results showed that the mechanisms behind the enhancing effect of organic acids differed for the two forms of iron. For ferric iron the organic acids promoted uptake both by chelation and by lowering the pH, whereas for ferrous iron the promoting effect was caused only by the lowered pH.
Susan Salovaara; Ann-Sofie Sandberg; Thomas Andlid
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  51     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-10     Completed Date:  2004-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7820-4     Citation Subset:  IM    
Department of Chemistry and Bioscience, Chalmers University of Technology, PO Box 5401, SE-402 29 Göteborg, Sweden.
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MeSH Terms
Caco-2 Cells
Carboxylic Acids / pharmacology*
Citric Acid / pharmacology
Ferric Compounds / metabolism
Ferrous Compounds / metabolism
Hydrochloric Acid
Hydrogen-Ion Concentration
Intestinal Absorption / drug effects*
Intestines / drug effects,  metabolism
Iron / metabolism*
Oxalic Acid / pharmacology
Propionic Acids / pharmacology
Succinic Acid / pharmacology
Tartrates / pharmacology
Reg. No./Substance:
0/Carboxylic Acids; 0/Ferric Compounds; 0/Ferrous Compounds; 0/Propionic Acids; 0/Solutions; 0/Tartrates; 110-15-6/Succinic Acid; 144-62-7/Oxalic Acid; 526-83-0/tartaric acid; 7439-89-6/Iron; 7647-01-0/Hydrochloric Acid; 77-92-9/Citric Acid; 79-09-4/propionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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