| Combined hyperlipidemia in a single subject with tetraplegia: ineffective risk reduction after atorvastatin monotherapy. | |
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MedLine Citation:
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PMID: 15648805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVE: Effects of atorvastatin (Lipitor) drug monotherapy (10 mg daily) on fasting blood lipid profiles and cardiovascular disease (CVD) risks were examined for a single subject with C5-C6 tetraplegia. Routine fasting lipid profiles were analyzed by standard biochemistry techniques for total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C). Lipid profiles were analyzed on 3 occasions before drug therapy was initiated and 3 months after therapy commenced. The TC:HDL and LDL:HDL ratios were computed for all sampling times and used to assess pretreatment and post-treatment CVD risk. RESULTS: Fasting TC, TG, and LDL-C were all significantly reduced by therapy. The pretreatment HDL-C of 35 mg/dL was lowered to 21 mg/dL. As a result, the TC:HDL risk ratio was only marginally reduced from 6.6 to 6.4, whereas the LDL:HDL risk ratio remained unchanged by treatment. CONCLUSIONS: In this man with tetraplegia, atorvastatin drug monotherapy rapidly lowered TC, TG, LDL-C, and HDL-C. However, the TC:HDL ratio, considered the best predictor of CVD risk, was unchanged. |
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Authors:
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Mark S Nash; Brad M Johnson; Patrick L Jacobs |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of spinal cord medicine Volume: 27 ISSN: 1079-0268 ISO Abbreviation: J Spinal Cord Med Publication Date: 2004 |
Date Detail:
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Created Date: 2005-01-14 Completed Date: 2005-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9504452 Medline TA: J Spinal Cord Med Country: United States |
Other Details:
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Languages: eng Pagination: 484-7 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA. msnash@miami.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticholesteremic Agents / therapeutic use* Cardiovascular Diseases / blood, prevention & control* Cervical Vertebrae / injuries Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Follow-Up Studies Heptanoic Acids / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hyperlipidemia, Familial Combined / blood, diagnosis, drug therapy* Male Odds Ratio Pyrroles / therapeutic use* Spinal Cord Injuries / blood* Treatment Failure Triglycerides / blood Wounds, Gunshot / blood* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 0/Triglycerides; 110862-48-1/atorvastatin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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