| Combined human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) treatment in gonadotropin-deficient males with pituitary dwarfism. | |
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MedLine Citation:
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PMID: 1621528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of hCG-hMG treatment in 13 boys with pituitary dwarfism associated with gonadotropin deficiency, were assessed. No patients except one showed signs of puberty at a bone age of 13 years or above. The one patient with some signs of puberty did not become fully mature. The hCG-hMG was started at a mean age of 20.4 years. The hCG at a dose of 5,000 IU was injected intramuscularly twice a week and the hMG at a dose of 75 IU was given once a week at first. During treatment, the frequency of hMG injections was increased to twice a week in six patients who still had not produced normal sperm counts. After a mean duration of 19.23 months, spermatozoa appeared in eight patients, of whom four showed more than 20 x 10(6) sperm/ml. Among six patients who did not have normal sperm counts and had increased hMG injections, one produced a pregnancy and four achieved sperm counts of more than 35 x 10(6)/ml. One patient had refractory azoospermia. In 13 boys with growth hormone and gonadotropin deficiency, hCG-hMG treatment produced normal spermatogenesis in nine patients, one of whom fathered a girl. Thus, hCG-hMG treatment, especially twice-a-week injections of both hCG and hMG, appears to be effective for gonadotropin deficiency in males. |
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Authors:
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T Tanaka; I Hibi; A Tanae |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica Japonica; Overseas edition Volume: 34 ISSN: 0374-5600 ISO Abbreviation: Acta Paediatr Jpn Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-08-06 Completed Date: 1992-08-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370357 Medline TA: Acta Paediatr Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 243-8; discussion 249-50 Citation Subset: IM |
Affiliation:
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Endocrine Research Laboratory, National Children's Medical Research Center, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chorionic Gonadotropin / administration & dosage, therapeutic use* Drug Combinations Dwarfism, Pituitary / drug therapy*, physiopathology Gonadotropins / deficiency* Humans Leydig Cells / metabolism Male Menotropins / administration & dosage, therapeutic use* Puberty Radioimmunoassay Sperm Count / drug effects Spermatogenesis / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Drug Combinations; 0/Gonadotropins; 61489-71-2/Menotropins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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