Document Detail

Combined human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) treatment in gonadotropin-deficient males with pituitary dwarfism.
MedLine Citation:
PMID:  1621528     Owner:  NLM     Status:  MEDLINE    
The effects of hCG-hMG treatment in 13 boys with pituitary dwarfism associated with gonadotropin deficiency, were assessed. No patients except one showed signs of puberty at a bone age of 13 years or above. The one patient with some signs of puberty did not become fully mature. The hCG-hMG was started at a mean age of 20.4 years. The hCG at a dose of 5,000 IU was injected intramuscularly twice a week and the hMG at a dose of 75 IU was given once a week at first. During treatment, the frequency of hMG injections was increased to twice a week in six patients who still had not produced normal sperm counts. After a mean duration of 19.23 months, spermatozoa appeared in eight patients, of whom four showed more than 20 x 10(6) sperm/ml. Among six patients who did not have normal sperm counts and had increased hMG injections, one produced a pregnancy and four achieved sperm counts of more than 35 x 10(6)/ml. One patient had refractory azoospermia. In 13 boys with growth hormone and gonadotropin deficiency, hCG-hMG treatment produced normal spermatogenesis in nine patients, one of whom fathered a girl. Thus, hCG-hMG treatment, especially twice-a-week injections of both hCG and hMG, appears to be effective for gonadotropin deficiency in males.
T Tanaka; I Hibi; A Tanae
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  34     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  243-8; discussion 249-50     Citation Subset:  IM    
Endocrine Research Laboratory, National Children's Medical Research Center, Japan.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage,  therapeutic use*
Drug Combinations
Dwarfism, Pituitary / drug therapy*,  physiopathology
Gonadotropins / deficiency*
Leydig Cells / metabolism
Menotropins / administration & dosage,  therapeutic use*
Sperm Count / drug effects
Spermatogenesis / drug effects
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Drug Combinations; 0/Gonadotropins; 61489-71-2/Menotropins

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