Document Detail

Combined gonadotropin releasing hormone agonist/human menopausal gonadotropin therapy (GnRH-a/hMG) in normal, high, and poor responders to hMG.
MedLine Citation:
PMID:  1826724     Owner:  NLM     Status:  MEDLINE    
Patients who failed to conceive after gonadotropin stimulation in in vitro fertilization treatment were classified into normal, high, or poor responders. They were routinely offered another cycle with a combination of a gonadotropin releasing hormone agonist and gonadotropin therapy (in order to evaluate whether this combined therapy could improve their response). The gonadotropin-induced cycle was compared with the combined therapy cycle. With the combination treatment, in the normal responders the phase of ovarian stimulation was significantly (P less than 0.001) prolonged, and the number of follicles and oocytes collected (5.7 +/- 0.7 vs 3.1 +/- 0.4) was increased, without any change in serum estradiol level compared to the control cycle. In high responders the number of oocytes was not modified by the combined treatment compared with the control cycle. However, serum estradiol level was significantly (P less than 0.005) decreased. The combined therapy did not modify any parameter of response in poor responders. We conclude that the response to combined agonist/gonadotropin therapy is dependent on the patient's own basal response. No improvement in response was expected in poor responders.
Z Ben-Rafael; D Bider; U Dan; M Zolti; D Levran; S Mashiach
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of in vitro fertilization and embryo transfer : IVF     Volume:  8     ISSN:  0740-7769     ISO Abbreviation:  J In Vitro Fert Embryo Transf     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-22     Completed Date:  1991-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412594     Medline TA:  J In Vitro Fert Embryo Transf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Tel Aviv University, Tel Hashomer, Israel.
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MeSH Terms
Delayed-Action Preparations
Drug Therapy, Combination
Estradiol / metabolism
Gonadotropin-Releasing Hormone / analogs & derivatives*,  pharmacology
Infertility, Female / drug therapy*
Luteolytic Agents / pharmacology*
Menotropins / pharmacology*
Ovary / drug effects*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Luteolytic Agents; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57773-63-4/Triptorelin; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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