| Combined furosemide and human albumin treatment for diuretic-resistant edema. | |
| | |
MedLine Citation:
|
PMID: 12708949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the clinical usefulness of combined furosemide and human albumin for the treatment of diuretic-resistant edema in patients with nephrotic syndrome and cirrhosis. DATA SOURCES: Clinical literature was accessed through MEDLINE (1966-May 2002). Key search terms included furosemide, albumin, human albumin solution, nephrotic syndrome, and cirrhosis. DATA SYNTHESIS: Hypoalbuminemia, edema, and ascites are often manifestations of nephrotic syndrome and cirrhosis of the liver. Many patients with these conditions are resistant to the effects of diuretics. The combination of furosemide and human albumin solution is occasionally used in these patients. An evaluation of published studies focusing on combined furosemide and albumin in the management of nephrotic syndrome and cirrhosis was conducted. CONCLUSIONS: Published studies report conflicting results regarding the efficacy of combined furosemide and albumin. Although it is difficult to generate firm conclusions, it appears the combination may provide clinical benefits for select patients. Given these findings, we believe that the addition of albumin to enhance diuretic efficacy should be reserved for patients with recalcitrant edema or ascites in whom diuretic doses have been maximized and those with severe hypoalbuminemia. |
| | |
Authors:
|
Rowland J Elwell; Ann P Spencer; George Eisele |
Related Documents
:
|
7563279 - Filarial antibody detection in suspected occult filariasis in children in an endemic area. 1580319 - Case report: nephrotic syndrome associated with a total hydatidiform mole. 2307999 - Utility of gallium imaging of the kidneys in diagnosing primary amyloid nephrotic syndr... 3712479 - Syndromes, communicative disorders, and black children. 7573199 - Nephrotic syndrome, malignant thymoma, and myasthenia gravis. case report and review of... 7055089 - Giant lymph node hyperplasia involving the thymus with associated nephrotic syndrome an... 17255789 - The role of lenalidomide in the treatment of patients with chromosome 5q deletion and o... 21653829 - Protein interactome reveals converging molecular pathways among autism disorders. 3480419 - Status asthmaticus associated with hyperthyroidism. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Annals of pharmacotherapy Volume: 37 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-04-23 Completed Date: 2003-06-23 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
|
Languages: eng Pagination: 695-700 Citation Subset: IM |
Affiliation:
|
Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208-3492, USA. elwellr@acp.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albumins
/
therapeutic use* Ascites / drug therapy Diuretics / therapeutic use* Drug Therapy, Combination Edema / drug therapy* Furosemide / therapeutic use* Humans Liver Cirrhosis / drug therapy Nephrotic Syndrome / drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Diuretics; 54-31-9/Furosemide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aripiprazole: a new atypical antipsychotic drug.
Next Document: Extended-release metoprolol succinate in chronic heart failure.