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Combined experimental and computational strategies define an expansive regulon for GcvB small RNA.
MedLine Citation:
PMID:  21815948     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid transporters and has been postulated to limit uptake of unnecessary amino acids under nutrient-rich conditions. In this issue of Molecular Microbiology, Sharma et al. (2011) provide evidence for a much broader role for GcvB as a global regulator of amino acid metabolism. Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date.
Authors:
Carin K Vanderpool
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-4
Journal Detail:
Title:  Molecular microbiology     Volume:  -     ISSN:  1365-2958     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
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