Document Detail

Combined evaluation of pupillary and cardiovascular responses to cold pressor test in cluster headache patients.
MedLine Citation:
PMID:  9950623     Owner:  NLM     Status:  MEDLINE    
Little is known about the structures and mechanisms involved in the pathophysiology of cluster headache (CH). In this study, pupillary and cardiovascular responses to the cold pressor test (CPT) were monitored in CH patients during either an active phase of disease or a remission period in order to evaluate the oculocephalic and cardiovascular functioning of the autonomic nervous system in this form of idiopathic headache. CH patients showed a specific pattern of pupillary response on both sides during both phases of the disease. This response differed from that of controls because of an absent miosis. The pressor response to CPT was more marked in CH patients than in controls. Naloxone pretreatment caused specific and selective changes in both the pupillary and cardiovascular responses of CH patients. These data suggest a systemic sympathetic hyperactivation in response to CPT in CH patients. An oculocephalic sympathetic hypofunction is possibly associated as well as an altered opioid neuromodulation.
C Tassorelli; G Micieli; V Osipova; S Marcheselli; F Rossi; G Nappi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  18     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  668-74     Citation Subset:  IM    
Headache Center and Autonomic Unit, Institute of Neurology IRCCS C. Mondino Foundation, University of Pavia, Italy.
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MeSH Terms
Blood Pressure / physiology*
Cardiovascular Physiological Phenomena*
Case-Control Studies
Cluster Headache / diagnosis*
Cold Temperature*
Evaluation Studies as Topic
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Pain Threshold / physiology
Pupil Disorders / diagnosis*
Remission Induction
Reproducibility of Results
Reg. No./Substance:
0/Narcotic Antagonists; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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