Document Detail

Combined effects of inhaled nitric oxide and positive end-expiratory pressure during mechanical ventilation in acute respiratory distress syndrome.
MedLine Citation:
PMID:  10848682     Owner:  NLM     Status:  MEDLINE    
We studied the combined effects of inhaled nitric oxide (INO) and positive end expiratory pressure (PEEP) during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). Eleven patients received 0 and 4 parts per million of INO in random order for 30 min at PEEP levels of 0, 5, and 10 cm H2O. Respiratory and cardiovascular parameters were measured. The addition of INO and PEEP significantly improved arterial oxygenation (p < 0.005 and p < 0.0001, respectively). The combined effect of INO and PEEP on arterial oxygenation was remarkable during 10 cm H2O PEEP. There was synergistic effect on arterial oxygenation by combining INO and 10 cm H2O PEEP. The present study showed that the combination of INO and 10 cm H2O PEEP enhanced arterial oxygenation in patients with ARDS.
K Okamoto; I Kukita; M Hamaguchi; T Motoyama; H Muranaka; T Harada
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  24     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-11     Completed Date:  2000-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  390-5     Citation Subset:  IM    
Division of Intensive and Critical Care Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.
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MeSH Terms
Administration, Inhalation
Aged, 80 and over
Analysis of Variance
Blood Pressure / drug effects
Bronchodilator Agents / administration & dosage,  therapeutic use*
Carbon Dioxide / blood
Cardiac Output / drug effects
Central Venous Pressure / drug effects
Middle Aged
Nitric Oxide / administration & dosage,  therapeutic use*
Oxygen / blood
Oxygen Consumption / drug effects
Positive-Pressure Respiration*
Pulmonary Gas Exchange / drug effects
Pulmonary Wedge Pressure / drug effects
Respiration / drug effects
Respiration, Artificial*
Respiratory Distress Syndrome, Adult / drug therapy,  therapy*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Bronchodilator Agents; 10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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