Document Detail


Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats.
MedLine Citation:
PMID:  11685434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ingested fluoride is incorporated into bone apatite and can affect the structural integrity of bone. Fluoride absorption in the gut and incorporation into bone is affected by the presence of other ions, including calcium. We hypothesized that a low calcium phosphate diet combined with high fluoride intake would have independent detrimental effects on vertebral bone strength. We measured the vertebral biomechanical properties and bone histology for rats given controlled diets with varied fluoride and calcium phosphate intakes for either 16 or 48 weeks. Diets were designed to produce mild calcium deficiency while keeping Ca:P ratio constant. Hence calcium deficiency was accompanied by a proportional phosphate deficiency. Calcium phosphate deficiency (25% of normal) significantly diminished vertebral strength only in younger rats. As the rats grew older, the effects of calcium phosphate deficiency were mitigated. Calcium phosphate deficiency reduced vertebral strength in young rats primarily by reducing the trabecular bone volume. The highest fluoride intake (50 mg/L) significantly diminished vertebral strength, but there was no effect of lower fluoride intakes on bone strength. In contrast to calcium phosphate deficiency, high fluoride intake had no effect on trabecular bone volume but instead increased the amount of unmineralized osteoid, particularly in older rats. This impairment of mineralization by fluoride appeared to be the primary cause of the diminished vertebral strength. The detrimental effects of fluoride on vertebral bone strength were not amplified by calcium phosphate deficiency.
Authors:
C H Turner; W R Hinckley; M E Wilson; W Zhang; A J Dunipace
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2001-06-15
Journal Detail:
Title:  Calcified tissue international     Volume:  69     ISSN:  0171-967X     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-10-31     Completed Date:  2002-01-03     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Affiliation:
Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects,  physiology
Calcification, Physiologic / drug effects
Calcium / deficiency*
Calcium Phosphates / administration & dosage
Calcium, Dietary / administration & dosage
Compressive Strength / drug effects,  physiology
Diet
Dose-Response Relationship, Drug
Fluorides / administration & dosage*,  adverse effects,  blood
Lumbar Vertebrae / drug effects*,  pathology,  physiopathology
Male
Phosphates / deficiency*
Rats
Rats, Sprague-Dawley
Weight-Bearing / physiology
Grant Support
ID/Acronym/Agency:
R01-DE11291/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 0/Calcium, Dietary; 0/Fluorides; 0/Phosphates; 0/alpha-tricalcium phosphate; 0/monocalcium phosphate; 0/tetracalcium phosphate; 7440-70-2/Calcium; 97Z1WI3NDX/calcium phosphate; L11K75P92J/dicalcium phosphate anhydrous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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