Document Detail

Combined effects of PPARgamma2 P12A and PPARalpha L162V polymorphisms on glucose and insulin homeostasis: the Québec Family Study.
MedLine Citation:
PMID:  14677049     Owner:  NLM     Status:  MEDLINE    
Peroxisome proliferator-activated receptors gamma2 and alpha are nuclear factors known to be important regulators of lipid and glucose metabolism. Two polymorphisms, namely PPARgamma2 P12A and PPARalpha L162V, were investigated for their individual and interaction effects on glucose and insulin homeostasis. Genotypes were determined in 663 nondiabetic adults participating in the Québec Family Study and who underwent an oral glucose tolerance test (OGTT). The insulin and C-peptide areas under the curve (AUC) following the OGTT were higher in subjects carrying the PPARalpha V162 allele compared to homozygous for the L162 allele. When subjects were grouped according to both polymorphisms, higher levels of insulin and C-peptide during the OGTT were observed for those carrying the PPARalpha V162 allele except when they carry at the same time the PPARgamma2 A12 allele. Thus, the PPARgamma2 A12 allele seems protective against the deleterious effect of the PPARalpha V162 allele. Furthermore, a significant gene-gene interaction was observed for the acute (0-30 min) (p<0.001) and the total (p=0.05) C-peptide AUC following the OGTT. These results provide evidence of a gene-gene interaction in the regulation of plasma glucose-insulin homeostasis, and emphasize that these interactions need to be taken into account when dissecting the genetic etiology of complex disorders.
Yohan Bossé; S John Weisnagel; Claude Bouchard; Jean-Pierre Després; Louis Pérusse; Marie-Claude Vohl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-11-20
Journal Detail:
Title:  Journal of human genetics     Volume:  48     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  614-21     Citation Subset:  IM    
Lipid Research Center, CHUL Research Center, Laval University, TR-93, 2705 Laurier Blvd, Sainte-Foy, Québec, G1V 4G2 Canada.
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MeSH Terms
Age Factors
Area Under Curve
C-Peptide / chemistry
Diabetes Mellitus, Type 2 / genetics
Family Health
Glucose / metabolism*
Glucose Tolerance Test
Insulin / metabolism*
Middle Aged
Peptides / chemistry
Polymorphism, Genetic*
Receptors, Cytoplasmic and Nuclear / genetics*
Time Factors
Transcription Factors / genetics*
Reg. No./Substance:
0/C-Peptide; 0/Peptides; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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