| Combined effect of denucleation and denitrogenation on the risk of decompression sickness in rats. | |
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MedLine Citation:
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PMID: 19228988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously hypothesized that the number of bubbles emerging on decompression from a dive, and the resultant risk of decompression sickness (DCS), may be reduced by a process whereby effective gas micronuclei that might otherwise have formed bubbles on decompression are shrunk and eliminated. In a procedure defined by us as denucleation, exposure to hyperbaric oxygen (HBO) would result in oxygen replacing the resident gas in the micronuclei, to be subsequently consumed by the mitochondria when the oxygen pressure is reduced. Support for the validity of our hypothesis may be found in our previous studies on the transparent prawn and the reduction of DCS in the rat. In all of these studies, HBO pretreatment was given before supersaturation with inert gas at high pressure. The purpose of the present study was to compare DCS outcome in rats that underwent nitrogen washout (denitrogenation) alone (9 min O(2) at 507 kPa) after exposure to air at high pressure (33 min at 1,266 kPa), and rats treated by both procedures (denitrogenation + denucleation; 8 min of O(2) breathing followed by 5 min air breathing, both at 507 kPa) after high-pressure air exposure. This was done with the same nitrogen load in both groups before the final decompression (a nitrogen pressure of 467 kPa in fatty and 488 kPa in aqueous tissue). Six of 20 rats in the denitrogenation + denucleation group died, compared with 13 in the denitrogenation group (P < 0.03). Three rats in the denitrogenation + denucleation group suffered mild DCS, recovering completely within 2 h of decompression. The present study indicates an advantage in considering both denitrogenation and denucleation before decompression. This may have practical application before escape from a disabled submarine, when aborting a technical dive, or in the preparation of aviators for high altitude. |
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Authors:
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R Arieli; E Boaron; A Abramovich |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-19 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 106 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-01 Completed Date: 2009-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1453-8 Citation Subset: IM |
Affiliation:
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Israel Naval Medical Institute, Israel Defense Force Medical Corps, Haifa, Israel. rarieli@netvision.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pressure Animals Atmosphere Exposure Chambers Decompression Decompression Sickness / mortality, physiopathology, therapy* Diving / physiology Gases / chemistry* Hyperbaric Oxygenation Male Mitochondria / metabolism Nanoparticles Nitrogen / therapeutic use* Noble Gases Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Gases; 0/Noble Gases; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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