| Combined dynamic contrast-enhancement and serial 3D-subtraction analysis in magnetic resonance imaging of osteoid osteomas. | |
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MedLine Citation:
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PMID: 19444454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to retrospectively correlate the results of dynamic contrast-enhanced magnetic resonance imaging (MRI) with histological and clinical diagnoses in patients with osteoid osteomas. Fifty-four patients with the MR diagnosis of osteoid osteoma were studied. MRI (1.5 Tesla) consisted of thin-section STIR sequences, dynamic 3D T1 gradient echo sequences during application of contrast material, and high-resolution postcontrast T1 spin echo sequences with fat saturation (maximum voxel size 0.6 x 0.6 x 3.0 mm). Evaluation was focused on serial image subtraction during the early phase after contrast injection and on time-intensity curves. The surrounding edema was helpful in finding the nidus in each lesion. In 49 of 54 patients (90.7%), the diagnosis of osteoid osteoma was certain or highly probable (sensitivity 1.0, positive predictive value 0.91). A total of 38 of 54 osteoid osteomas were histologically proven. Five MRI diagnoses were regarded as false positives. A similar proportion has been reported for computed tomography. Tailored high-resolution MR examinations with dynamic contrast enhancement can reliably diagnose osteoid osteomas and exactly localize the nidus without radiation exposure. We propose a stepwise approach with STIR sequences, dynamic contrast-enhanced scanning, and high-resolution postcontrast T1 spin echo sequences with fat saturation. |
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Authors:
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T von Kalle; M Langend??rfer; F F Fernandez; P Winkler |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-05-15 |
Journal Detail:
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Title: European radiology Volume: 19 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2508-17 Citation Subset: IM |
Affiliation:
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Department of Paediatric Radiology, Klinikum Stuttgart Olgahospital, Bismarckstr. 8, 70176, Stuttgart, Germany. t.vonkalle@klinikum-stuttgart.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Algorithms Bone Neoplasms / diagnosis* Child Child, Preschool Contrast Media Female Gadolinium DTPA / diagnostic use* Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods Imaging, Three-Dimensional / methods* Infant Magnetic Resonance Imaging / methods* Male Osteoma, Osteoid / diagnosis* Reproducibility of Results Sensitivity and Specificity Subtraction Technique* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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