| Combined dipyridamole and dobutamine echocardiography in myocardial hibernation: comparison with thallium uptake in patients after percutaneous transluminal coronary revascularization under circulatory support. | |
MedLine Citation:
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PMID: 11696828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the specificity and sensitivity of the combination of dipyridamole and dobutamine echocardiography for predicting functional recovery in patients with reduced ventricular function after coronary angioplasty. METHODS: Twenty-five patients, mean (SD) age 60.8 (10) years, with previous myocardial infarction (> 3 months), angiographically assessed coronary artery disease, and resting regional dysfunction (left ventricular ejection fraction < 35%) were studied. They underwent rest-redistribution thallium Tl-201 single photon emission computed tomography, and low-dose pharmacologic stress echocardiography with dobutamine (up to 10 microg/kg per minute), ultra low-dose dipyridamole (0.28 mg/kg over 4 minutes), and combined dipyridamole-dobutamine administration. RESULTS: The rate of agreement between Tl-201 and stress echo was 59% for dipyridamole, 62% for dobutamine, and 71% for combined dipyridamole-dobutamine (P <.05 vs dipyridamole and vs dobutamine). Combined dipyridamole-dobutamine showed a higher sensitivity (89%) than Tl-201, dobutamine, or dipyridamole (84%, 78%, and 80%). Specificity was lower for functional recovery prediction with Tl-201 (60%) compared with dobutamine (89%), dipyridamole (90%), and combined dipyridamole-dobutamine (91%). CONCLUSION: Thallium is more sensitive than dipyridamole or dobutamine; the sensitivity gap is filled with combined dipyridamole-dobutamine. Pharmacologic stress echocardiography is more specific than Tl-201 scintigraphy. |
Authors:
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A C Borges; W S Richter; M Witzel; C Witzel; A Grohmann; G Baumann |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 14 ISSN: 0894-7317 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-06 Completed Date: 2001-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 1057-64 Citation Subset: IM |
Affiliation:
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Medical Department I, Charité, Berlin, Schumannstrasse 20-21, 10117 Berlin--Germany. adrian.borges@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioplasty, Transluminal, Percutaneous Coronary* Cardiotonic Agents / diagnostic use* Coronary Disease / complications, therapy* Dipyridamole / diagnostic use* Dobutamine / diagnostic use* Echocardiography, Stress Female Follow-Up Studies Humans Male Middle Aged Myocardial Stunning / etiology, radionuclide imaging*, ultrasonography* Sensitivity and Specificity Thallium Radioisotopes / diagnostic use* Tomography, Emission-Computed, Single-Photon Vasodilator Agents / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Thallium Radioisotopes; 0/Vasodilator Agents; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole |
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