Document Detail

Combined dipyridamole and dobutamine echocardiography in myocardial hibernation: comparison with thallium uptake in patients after percutaneous transluminal coronary revascularization under circulatory support.
MedLine Citation:
PMID:  11696828     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the specificity and sensitivity of the combination of dipyridamole and dobutamine echocardiography for predicting functional recovery in patients with reduced ventricular function after coronary angioplasty. METHODS: Twenty-five patients, mean (SD) age 60.8 (10) years, with previous myocardial infarction (> 3 months), angiographically assessed coronary artery disease, and resting regional dysfunction (left ventricular ejection fraction < 35%) were studied. They underwent rest-redistribution thallium Tl-201 single photon emission computed tomography, and low-dose pharmacologic stress echocardiography with dobutamine (up to 10 microg/kg per minute), ultra low-dose dipyridamole (0.28 mg/kg over 4 minutes), and combined dipyridamole-dobutamine administration. RESULTS: The rate of agreement between Tl-201 and stress echo was 59% for dipyridamole, 62% for dobutamine, and 71% for combined dipyridamole-dobutamine (P <.05 vs dipyridamole and vs dobutamine). Combined dipyridamole-dobutamine showed a higher sensitivity (89%) than Tl-201, dobutamine, or dipyridamole (84%, 78%, and 80%). Specificity was lower for functional recovery prediction with Tl-201 (60%) compared with dobutamine (89%), dipyridamole (90%), and combined dipyridamole-dobutamine (91%). CONCLUSION: Thallium is more sensitive than dipyridamole or dobutamine; the sensitivity gap is filled with combined dipyridamole-dobutamine. Pharmacologic stress echocardiography is more specific than Tl-201 scintigraphy.
A C Borges; W S Richter; M Witzel; C Witzel; A Grohmann; G Baumann
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  14     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-06     Completed Date:  2001-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-64     Citation Subset:  IM    
Medical Department I, Charité, Berlin, Schumannstrasse 20-21, 10117 Berlin--Germany.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Cardiotonic Agents / diagnostic use*
Coronary Disease / complications,  therapy*
Dipyridamole / diagnostic use*
Dobutamine / diagnostic use*
Echocardiography, Stress
Follow-Up Studies
Middle Aged
Myocardial Stunning / etiology,  radionuclide imaging*,  ultrasonography*
Sensitivity and Specificity
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon
Vasodilator Agents / diagnostic use*
Reg. No./Substance:
0/Cardiotonic Agents; 0/Thallium Radioisotopes; 0/Vasodilator Agents; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole

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