Document Detail

Combined dieting and stress evoke exaggerated responses to opioids in binge-eating rats.
MedLine Citation:
PMID:  16300427     Owner:  NLM     Status:  MEDLINE    
The authors developed an animal model of binge eating where history of caloric restriction with footshock stress (R + S) causes rats to consume twice the normal amount of palatable food. The authors tested the hypothesis that binge eating is mediated by changes in opioid control of feeding by comparing rats' anorectic and orexigenic responses to naloxone and butorphanol, respectively, and by testing the ability of butorphanol to elicit binge eating of chow when palatable food was absent. Mu/kappa opioid-receptor blockade and activation had exaggerated responses in the R + S rats with naloxone suppressing binge eating to control levels, and although butorphanol did not trigger chow binge eating, it enhanced binge eating of palatable food. These responses in sated normal-weight rats strengthen evidence that reward, over metabolic need, drives binge eating.
Mary M Boggiano; Paula C Chandler; Jason B Viana; Kimberly D Oswald; Christine R Maldonado; Pamela K Wauford
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  119     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2006-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1207-14     Citation Subset:  IM    
Department of Psychology, Behavioral Neuroscience Division, University of Alabama at Birmingham, AL 35294-1170, USA.
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MeSH Terms
Analgesics, Opioid / pharmacology
Analysis of Variance
Behavior, Animal
Body Weight / drug effects,  physiology
Bulimia / etiology*
Butorphanol / pharmacology
Caloric Restriction / methods*
Disease Models, Animal
Electroshock / adverse effects*
Energy Intake / drug effects,  physiology
Feeding Behavior / drug effects*
Food Preferences / drug effects,  physiology
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Narcotics / metabolism*
Rats, Sprague-Dawley
Time Factors
Grant Support
R03-066007//PHS HHS
Reg. No./Substance:
0/Analgesics, Opioid; 0/Narcotic Antagonists; 0/Narcotics; 42408-82-2/Butorphanol; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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