Document Detail

Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion.
MedLine Citation:
PMID:  23273362     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The purposes of this research were to investigate the long-term responses of mandibular condylar cartilage to experimentally induced disordered occlusion and to evaluate changes in the expression of the SDF-1/CXCR4 axis.
METHODS: Experimentally induced disordered occlusions were created in 8-week-old female Sprague-Dawley rats by orthodontic methods. After 24 weeks, remodeling of the mandibular condylar cartilage was assessed by hematoxylin and eosin staining. Protein and mRNA expression of SDF-1, CXCR4, MMP9, IL6, OPG, and RANKL were investigated by means of immunohistochemical staining and real-time polymerase chain reaction.
RESULTS: Obvious cartilage degenerative remodeling responses were observed; they appeared as uneven distributions of cellular disposition, loss of cartilage surface integrity, and cell-free areas. Regenerative responses presenting as thickening of the whole and the calcified cartilage layers in the experimental group were also observed. Compared with the age-matched controls, the protein and mRNA levels of SDF-1, CXCR4, MMP9, IL6, and OPG, but not RANKL, were increased in the experimental group (all, P <0.05). In addition, the mRNA level of RANKL/OPG showed a decreasing trend in the experimental group compared with the age-matched controls (P = 0.052).
CONCLUSIONS: This study demonstrated that long-term experimentally induced disordered occlusion leads to a combined response in degeneration and regeneration of mandibular cartilage, accompanied by active interaction of the SDF-1/CXCR4 axis and local upregulation of MMP9, IL6, and OPG.
Bin Kuang; Juan Dai; Qing-Yu Wang; Rong Song; Kai Jiao; Jie Zhang; Xiao-Guang Tian; Yin-Zhong Duan; Mei-Qing Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  143     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
Postgraduate student, Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China; associate chief dentist, Department of Stomatology, First People's Hospital, Lanzhou, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optical coherence tomography for debonding evaluation: An in-vitro qualitative study.
Next Document:  Quantification of external root resorption by low- vs high-resolution cone-beam computed tomography ...