| Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion. | |
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MedLine Citation:
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PMID: 23273362 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: The purposes of this research were to investigate the long-term responses of mandibular condylar cartilage to experimentally induced disordered occlusion and to evaluate changes in the expression of the SDF-1/CXCR4 axis. METHODS: Experimentally induced disordered occlusions were created in 8-week-old female Sprague-Dawley rats by orthodontic methods. After 24 weeks, remodeling of the mandibular condylar cartilage was assessed by hematoxylin and eosin staining. Protein and mRNA expression of SDF-1, CXCR4, MMP9, IL6, OPG, and RANKL were investigated by means of immunohistochemical staining and real-time polymerase chain reaction. RESULTS: Obvious cartilage degenerative remodeling responses were observed; they appeared as uneven distributions of cellular disposition, loss of cartilage surface integrity, and cell-free areas. Regenerative responses presenting as thickening of the whole and the calcified cartilage layers in the experimental group were also observed. Compared with the age-matched controls, the protein and mRNA levels of SDF-1, CXCR4, MMP9, IL6, and OPG, but not RANKL, were increased in the experimental group (all, P <0.05). In addition, the mRNA level of RANKL/OPG showed a decreasing trend in the experimental group compared with the age-matched controls (P = 0.052). CONCLUSIONS: This study demonstrated that long-term experimentally induced disordered occlusion leads to a combined response in degeneration and regeneration of mandibular cartilage, accompanied by active interaction of the SDF-1/CXCR4 axis and local upregulation of MMP9, IL6, and OPG. |
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Authors:
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Bin Kuang; Juan Dai; Qing-Yu Wang; Rong Song; Kai Jiao; Jie Zhang; Xiao-Guang Tian; Yin-Zhong Duan; Mei-Qing Wang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics Volume: 143 ISSN: 1097-6752 ISO Abbreviation: Am J Orthod Dentofacial Orthop Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610224 Medline TA: Am J Orthod Dentofacial Orthop Country: United States |
Other Details:
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Languages: eng Pagination: 69-76 Citation Subset: D; IM |
Copyright Information:
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Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Postgraduate student, Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China; associate chief dentist, Department of Stomatology, First People's Hospital, Lanzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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