Document Detail

Combined clonidine-chlorthalidone therapy in hypertension. Two years' experience in 30 patients.
MedLine Citation:
PMID:  1164125     Owner:  NLM     Status:  MEDLINE    
The efficacy and safety of the antihypertensive drug, clonidine, were tested by open-label trial in 30 ambulatory, hypertensive patients who were concomitantly receiving the diuretic, chlorthalidone. This combined treatment followed several weeks of base line treatment with the diuretic alone. In both the recumbent and the upright position, clonidine potentiated the blood pressure-lowering effect of chlorthalidone to a noticeable degree; with combined treatment, the reductions in systolic and diastolic pressures were from 12.9% to 16.4% greater. Side-effects, consisting mostly of drowsiness and dryness of mouth, were mild and were observed mainly at the beginning of clonidine therapy. Orthostatic hypotension or weakness was experienced by 3 patients, but it subsided after dose adjustment in two of them. The drug combination was well suited for long-term management of patients with hypertension of all degrees of severity.
R H Rosenman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  135     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1236-9     Citation Subset:  AIM; IM    
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MeSH Terms
Chlorthalidone / administration & dosage,  adverse effects,  therapeutic use*
Clonidine / administration & dosage,  adverse effects,  therapeutic use*
Drug Therapy, Combination
Hypertension / drug therapy*
Middle Aged
Reg. No./Substance:
4205-90-7/Clonidine; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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