Document Detail

Combined chemotherapy and teratogenicity.
MedLine Citation:
PMID:  16104005     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The concomitant occurrence of breast cancer and pregnancy is relatively uncommon. We report the case of a patient with syndactyly, cleft hands, and absence of distal finger phalanges associated with maternal exposure to chemotherapeutic agents during the first trimester of pregnancy. These associations have not been previously described. CASE: The patient was born by normal delivery after 38 weeks of pregnancy. His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy. At birth, anomalies were observed, including a high-arched palate, microcephaly, a flat nasal bridge, bilateral syndactyly in the first and second fingers with a hand cleft between the second and third fingers and hypoplasia of the fifth fingers, and dystrophic nail of the fourth finger of the left hand. The patient's growth and development were deficient. CONCLUSIONS: The malformations associated with in utero exposure to these chemotherapeutic agents are highly variable, but growth deficiency and anomalies of the craniofacial region and limbs are the most common. The pattern of malformations in children who were congenitally exposed to chemotherapeutic agents appears to be directly related to the age at and duration of exposure, rather than to the specific drug itself. Effective contraception is essential for the safe use of a potential teratogen in nonpregnant women of reproductive age.
Giorgio Adriano Paskulin; Paulo Ricardo Gazzola Zen; Louise Lapagesse de Camargo Pinto; Rafael Rosa; Carla Graziadio
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  73     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-20     Completed Date:  2006-01-12     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  634-7     Citation Subset:  IM    
Copyright Information:
Birth Defects Research (Part A), 2005. (c) 2005 Wiley-Liss, Inc.
Disciplina de Genética Clínica e Programa de Pós-Graduação em Patologia, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Porto Alegre, Brazil.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*,  pathology,  radiography
Abnormalities, Multiple / chemically induced*,  pathology,  radiography
Antibiotics, Antineoplastic / toxicity
Antimetabolites, Antineoplastic / toxicity
Antineoplastic Agents, Alkylating / toxicity
Antineoplastic Combined Chemotherapy Protocols / toxicity*
Breast Neoplasms / drug therapy*
Child, Preschool
Cyclophosphamide / toxicity
Developmental Disabilities / chemically induced
Doxorubicin / toxicity
Drug Therapy, Combination
Fluorouracil / toxicity
Maternal-Fetal Exchange / drug effects
Microcephaly / chemically induced
Pregnancy Complications, Neoplastic / drug therapy*,  etiology
Pregnancy Trimester, Third
Syndactyly / etiology,  radiography
Teratogens / toxicity*
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents, Alkylating; 0/Teratogens; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil

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