| Combined chemotherapy and teratogenicity. | |
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MedLine Citation:
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PMID: 16104005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The concomitant occurrence of breast cancer and pregnancy is relatively uncommon. We report the case of a patient with syndactyly, cleft hands, and absence of distal finger phalanges associated with maternal exposure to chemotherapeutic agents during the first trimester of pregnancy. These associations have not been previously described. CASE: The patient was born by normal delivery after 38 weeks of pregnancy. His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy. At birth, anomalies were observed, including a high-arched palate, microcephaly, a flat nasal bridge, bilateral syndactyly in the first and second fingers with a hand cleft between the second and third fingers and hypoplasia of the fifth fingers, and dystrophic nail of the fourth finger of the left hand. The patient's growth and development were deficient. CONCLUSIONS: The malformations associated with in utero exposure to these chemotherapeutic agents are highly variable, but growth deficiency and anomalies of the craniofacial region and limbs are the most common. The pattern of malformations in children who were congenitally exposed to chemotherapeutic agents appears to be directly related to the age at and duration of exposure, rather than to the specific drug itself. Effective contraception is essential for the safe use of a potential teratogen in nonpregnant women of reproductive age. |
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Authors:
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Giorgio Adriano Paskulin; Paulo Ricardo Gazzola Zen; Louise Lapagesse de Camargo Pinto; Rafael Rosa; Carla Graziadio |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 73 ISSN: 1542-0752 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-20 Completed Date: 2006-01-12 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 634-7 Citation Subset: IM |
Copyright Information:
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Birth Defects Research (Part A), 2005. (c) 2005 Wiley-Liss, Inc. |
Affiliation:
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Disciplina de Genética Clínica e Programa de Pós-Graduação em Patologia, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Porto Alegre, Brazil. paskulin@fffcmpa.tche.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
/
etiology*,
pathology,
radiography Abnormalities, Multiple / chemically induced*, pathology, radiography Adult Antibiotics, Antineoplastic / toxicity Antimetabolites, Antineoplastic / toxicity Antineoplastic Agents, Alkylating / toxicity Antineoplastic Combined Chemotherapy Protocols / toxicity* Breast Neoplasms / drug therapy* Child, Preschool Cyclophosphamide / toxicity Developmental Disabilities / chemically induced Doxorubicin / toxicity Drug Therapy, Combination Female Fluorouracil / toxicity Humans Male Maternal-Fetal Exchange / drug effects Microcephaly / chemically induced Pregnancy Pregnancy Complications, Neoplastic / drug therapy*, etiology Pregnancy Trimester, Third Syndactyly / etiology, radiography Teratogens / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents, Alkylating; 0/Teratogens; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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