| Combined chemo-radiotherapy for locally advanced non-small cell lung cancer: current status and future development. | |
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MedLine Citation:
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PMID: 18632283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Currently, combinations of chemotherapy and radiotherapy are the standard treatment approach for locally advanced NSCLC patients. Concomitant chemo-radiotherapy, although associated with increased acute toxicity, has demonstrated to be the better strategy over sequential chemoradiotherapy, and it is to be considered a standard approach in patients with good performance status (0-1). However, the approach to locally advanced NSCLC and to chemo-radiotherapy regimens remains heterogeneous among oncologists, and clinical outcomes are yet disappointing. Thus, the search of new strategies is mandatory. The main fields of research aiming at improving the survival of locally advanced NSCLC patients are: the addition of further combination chemotherapy as induction or consolidation to concurrent chemo-radiotherapy, and the integration of molecularly targeted therapies into conventional chemo-radiotherapy regimens. |
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Authors:
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Cesare Guida; Paolo Maione; Antonio Rossi; Marianna Bareschino; Clorinda Schettino; Domenico Barzaghi; Massimo Elmo; Cesare Gridelli |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-07-15 |
Journal Detail:
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Title: Critical reviews in oncology/hematology Volume: 68 ISSN: 1040-8428 ISO Abbreviation: Crit. Rev. Oncol. Hematol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8916049 Medline TA: Crit Rev Oncol Hematol Country: Ireland |
Other Details:
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Languages: eng Pagination: 222-32 Citation Subset: IM |
Affiliation:
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Division of Radiotherapy, S.G. Moscati Hospital, Avellino, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Non-Small-Cell Lung
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drug therapy*,
mortality,
radiotherapy* Combined Modality Therapy / methods Humans Lung Neoplasms / drug therapy*, mortality, radiotherapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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