Document Detail

Combined carcinoembryonic antigen and cytopathologic examination in ascites.
MedLine Citation:
PMID:  11015979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate use of the combined carcinoembryonic antigen (CEA) test and cytopathologic examination to improve the diagnosis of neoplastic vs. nonneoplastic ascites. STUDY DESIGN: The tests were performed prospectively on 130 patients with ascites whose effusions were submitted for cytologic examination. RESULTS: Sixty-seven patients had epithelial tumors, and the cytologic examination was positive in 39 (58.2%). The CEA level was > or = 11.0 ng/mL in 36 patients (53.73%). CEA was helpful in the diagnosis in 18 cases, increasing to 57 (85.07%) the number of positive diagnoses. Eight samples of nonepithelial tumors had low levels of CEA. In 55 patients with nonneoplasic ascites the cytopathologic examination was negative, but the CEA assay was > 11.0 ng/mL in 3 patients. CONCLUSION: The cytopathologic examination should be performed in all cases, and the CEA assay should be done in suspected cases of epithelial neoplasia in which the cytologic examination was negative, there was uncertainty about the histologic type of neoplasia, or a diagnosis of nonepithelial neoplasia was made. When ascitic leukocytosis or hepatic failure is present, one should be cautious in interpreting the CEA assay because false positivity can occur.
R J Torresini; J C Prolla; A R Diehl; E K Morais; L F Jobim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  44     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  778-82     Citation Subset:  IM    
Department of Internal Medicine, Federal University of Rio Grande do Sul, Brazil.
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MeSH Terms
Ascites / immunology*,  pathology*
Carcinoembryonic Antigen / analysis*
Neoplasms / diagnosis,  immunology*,  pathology*
Predictive Value of Tests
Sensitivity and Specificity
Tumor Markers, Biological*
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Tumor Markers, Biological

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