Document Detail


Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise.
MedLine Citation:
PMID:  21766055     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking. METHODS: The present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect. RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein. CONCLUSIONS: Overall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.
Authors:
Fabio Penna; Silvia Busquets; Fabrizio Pin; Miriam Toledo; Francesco M Baccino; Francisco J López-Soriano; Paola Costelli; Josep M Argilés
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-11
Journal Detail:
Title:  Journal of cachexia, sarcopenia and muscle     Volume:  2     ISSN:  2190-6009     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101552883     Medline TA:  J Cachex Sarcopenia Muscle     Country:  -    
Other Details:
Languages:  ENG     Pagination:  95-104     Citation Subset:  -    
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