Document Detail

Combined antipsychotic treatment involving clozapine and aripiprazole.
MedLine Citation:
PMID:  18407391     Owner:  NLM     Status:  MEDLINE    
Treatment resistance is considered a challenging problem of antipsychotic pharmacotherapy. In such cases, combination approaches are commonly used, for instance the add-on of aripiprazole to clozapine. This review aims at giving an overview of the present knowledge on this strategy. We performed a keyword-based screening of databases (including November 2007) and evaluated the data in a systematic manner. The courses of 94 patients were reported in 11 publications. At a mean dosage of 20.5 mg/day, aripiprazole achieved clinical improvement of psychotic symptoms and facilitated a dose reduction of clozapine from 476.7 to 425.1 mg/day. In parallel, clozapine serum levels decreased from 611 to 523 ng/ml. No pharmacokinetic interactions were reported, and clozapine-induced side effects ameliorated. However, single cases of extrapyramidal side effects occurred. The combination of clozapine and aripiprazole follows a neurobiological rationale and appears to be effective and tolerable. The results of placebo-controlled trials might allow further insight into the benefits and risks of this strategy.
Susanne Englisch; Mathias Zink
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-29
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  32     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-22     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1386-92     Citation Subset:  IM    
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, University of Heidelberg, Mannheim, Germany.
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Clozapine / therapeutic use*
Drug Therapy, Combination
Piperazines / therapeutic use*
Psychotic Disorders / drug therapy*
Quinolones / therapeutic use*
Randomized Controlled Trials as Topic
Weight Loss / drug effects
Reg. No./Substance:
0/Antipsychotic Agents; 0/Piperazines; 0/Quinolones; 5786-21-0/Clozapine; 82VFR53I78/aripiprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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