Document Detail


Combined analysis with copy number variation identifies risk Loci in lung cancer.
MedLine Citation:
PMID:  25093167     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background. Lung cancer is the most important cause of cancer mortality worldwide, but the underlying mechanisms of this disease are not fully understood. Copy number variations (CNVs) are promising genetic variations to study because of their potential effects on cancer. Methodology/Principal Findings. Here we conducted a pilot study in which we systematically analyzed the association of CNVs in two lung cancer datasets: the Environment And Genetics in Lung cancer Etiology (EAGLE) and the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial datasets. We used a preestablished association method to test the datasets separately and conducted a combined analysis to test the association accordance between the two datasets. Finally, we identified 167 risk SNP loci and 22 CNVs associated with lung cancer and linked them with recombination hotspots. Functional annotation and biological relevance analyses implied that some of our predicted risk loci were supported by other studies and might be potential candidate loci for lung cancer studies. Conclusions/Significance. Our results further emphasized the importance of copy number variations in cancer and might be a valuable complement to current genome-wide association studies on cancer.
Authors:
Xinlei Li; Xianfeng Chen; Guohong Hu; Yang Liu; Zhenguo Zhang; Ping Wang; You Zhou; Xianfu Yi; Jie Zhang; Yufei Zhu; Zejun Wei; Fei Yuan; Guoping Zhao; Jun Zhu; Landian Hu; Xiangyin Kong
Related Documents :
24535227 - Integrative genomic analyses of the histamine h1 receptor and its role in cancer predic...
24165727 - Mining the epigenetic landscape in all.
10673967 - Effective communication skills are the key to good cancer care.
25109877 - Multiplatform analysis of 12 cancer types reveals molecular classification within and a...
9891497 - Inhibition of adriamycin cardiotoxicity by 5-fluorouracil: a potential free oxygen radi...
8649827 - Expression of the jun family of genes in human ovarian cancer and normal ovarian surfac...
Publication Detail:
Type:  Journal Article     Date:  2014-07-01
Journal Detail:
Title:  BioMed research international     Volume:  2014     ISSN:  2314-6141     ISO Abbreviation:  Biomed Res Int     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101600173     Medline TA:  Biomed Res Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469103     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biocatalytic Synthesis of Flavor Ester "Pentyl Valerate" Using Candida rugosa Lipase Immobilized in ...
Next Document:  Side of limb-onset predicts laterality of gray matter loss in amyotrophic lateral sclerosis.