| Combined iron/folic acid supplements and malaria prophylaxis reduce neonatal mortality in 19 sub-Saharan African countries. | |
| | |
MedLine Citation:
|
PMID: 20504976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: In nonmalaria regions, iron/folic acid supplementation during pregnancy protects newborns against preterm delivery and early neonatal death. Other studies from malaria-endemic areas have reported an adverse effect of iron supplements on malaria prevalence in pregnant women. OBJECTIVE: We examined the association between iron/folic acid supplements and prenatal antimalaria prophylaxis on neonatal mortality in malaria-endemic countries of sub-Saharan Africa. DESIGN: This analysis used the most recent data from Demographic and Health Surveys of 19 malaria-endemic countries in sub-Saharan Africa. Survival information of 101,636 singleton live-born infants from the most recent delivery of ever-married women < or =5 y before each survey was examined. The effect of each potential predictor on neonatal deaths was analyzed by using Cox proportional hazards regression models. RESULTS: Infants whose mothers received any iron/folic acid supplements and sulfadoxine-pyrimethamine intermittent preventive treatment (SP-IPT(p)) for malaria during pregnancy were significantly protected from neonatal death [hazard ratio (HR): 0.76; 95% CI: 0.58, 0.99]. The protective effect was not significant in mothers who received only iron/folic acid supplements (HR: 0.90; 95% CI: 0.73, 1.12) or only SP-IPT(p) (HR: 1.08; 95% CI: 0.74, 1.57). Among the sociodemographic and birth characteristics, factors that significantly increased the risk of neonatal death included first-born infants, a birth interval of <2 y, maternal age at delivery of > or =30 y, smaller than average-sized infants, and male infants. CONCLUSION: The use of antenatal iron/folic acid supplements combined with appropriate intermittent preventive treatment of malaria during pregnancy is an important intervention to reduce neonatal mortality in malaria-endemic regions. |
| | |
Authors:
|
Christiana R Titaley; Michael J Dibley; Christine L Roberts; Kingsley Agho |
Related Documents
:
|
16183576 - Obstetric impact of anaemia in pregnant women in united arab emirates. 12368396 - Estimation of the effect of the acute phase response on indicators of micronutrient sta... 7332896 - Iron intake of infants: the importance of infant cereals. 22187776 - Asymmetric conjoined twins: pyopagus parasite. 20308766 - Transient tone abnormalities in high risk infants and cognitive outcome at five years. 9350306 - Fatty acid oxidation disorders as primary cause of sudden and unexpected death in infan... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-21 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 235-43 Citation Subset: AIM; IM |
Affiliation:
|
Sydney School of Public Health, University of Sydney, Sydney, Australia. ctitaley@health.usyd.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Africa South of the Sahara
/
epidemiology Child Health Services / standards Delivery of Health Care / standards Demography Dietary Supplements Female Folic Acid / therapeutic use* Health Surveys Humans Infant Mortality / trends* Infant, Newborn Iron / therapeutic use* Malaria / prevention & control* Male Maternal Health Services / standards Pregnancy |
| Chemical | |
Reg. No./Substance:
|
59-30-3/Folic Acid; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Puberty and observed energy intake: boy, can they eat!
Next Document: Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metab...