| Combined use of contrast-enhanced intraoperative ultrasonography and a fluorescence navigation system for identifying hepatic metastases. | |
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MedLine Citation:
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PMID: 20734045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of this study was to assess the concomitant use of contrast-enhanced intraoperative ultrasound (CE-IOUS) using the new microbubble agent Sonazoid, and to assess the fluorescence navigation system (Photo Dynamic Eye, or PDE) using indocyanine green (ICG) as a novel tool for identifying colorectal metastatic lesions compared with preoperative contrast-enhanced multiple row-detected computed tomography (MDCT) and gadoxetic acid-enhanced MRI. METHODS: Thirty-two patients who underwent a liver resection for colorectal metastatic carcinoma from 2008 to 2009 were included in the present study. ICG was intravenously injected within 2 weeks of the operation. The liver was inspected with CE-IOUS using Sonazoid and PDE for visualizing small metastatic lesions. A lesion analysis was performed with the postoperative histopathological examination of the resected tissues. The clinical values of CE-IOUS and PDE to confirm the malignant lesion diagnoses were statistically evaluated. RESULTS: A total of 56 lesions were identified based on the histopathological findings of the biopsies and resected tissues; of these, 52 were confirmed to be metastases, whereas 4 were benign tumors. The numbers of identified metastases by MDCT/MRI and CE-IOUS/PDE were 46 and 51, respectively. The use of CE-IOUS and PDE improved the diagnostic sensitivity compared with the use of MDCT and EOB-MRI (98.1 vs. 88.5%, respectively; P = 0.050). CONCLUSIONS: The present results suggested that the concomitant use of CE-IOUS with the Sonazoid and PDE system may be a useful and safe method, in addition to CT or MRI. |
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Authors:
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Kazuhisa Uchiyama; Masaki Ueno; Satoru Ozawa; Sigehisa Kiriyama; Yoshinobu Shigekawa; Hiroki Yamaue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of surgery Volume: 34 ISSN: 1432-2323 ISO Abbreviation: World J Surg Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-04-05 Revised Date: 2011-12-12 |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 2953-9 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 641-8510, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Colorectal Neoplasms / pathology* Contrast Media / diagnostic use* Female Ferric Compounds / diagnostic use Fluorescent Dyes / diagnostic use* Gadolinium DTPA / diagnostic use Hepatectomy Humans Indocyanine Green / diagnostic use Intraoperative Period Iron / diagnostic use Liver Neoplasms / diagnosis*, secondary, surgery Magnetic Resonance Imaging Male Middle Aged Oxides / diagnostic use Tomography, X-Ray Computed Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Ferric Compounds; 0/Fluorescent Dyes; 0/Oxides; 0/Sonazoid; 0/gadolinium ethoxybenzyl DTPA; 3599-32-4/Indocyanine Green; 7439-89-6/Iron; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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