Document Detail

A Combined Trauma Model of Chest and Abdominal Trauma With Hemorrhagic Shock - Description of a new Porcine Model.
MedLine Citation:
PMID:  23042201     Owner:  NLM     Status:  Publisher    
ABSTRACT: Despite the high incidence and prognostic relevance of hemorrhagic shock, abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma model consisting of blunt chest trauma, penetrating abdominal trauma (two incisions in the right upper liver lobe using a four-edged scalpel and subsequent liver packing) and pressure-controlled hemorrhagic shock with a mean arterial pressure of 30 ± 5 mmHg (a maximum of 45% of the total blood volume). The combined traumatic insult led to severe signs of hemorrhagic shock and impaired pulmonary function.In conclusion, a consistent, reproducible and clinically relevant porcine model of multi-system injury with controlled (pressure-controlled blood withdrawal) and uncontrolled components of hemorrhage (liver laceration) with the potential for re-bleeding was established.
F Hildebrand; M Weuster; P Mommsen; J Mohr; M Fröhlich; I Witte; C Keibl; S Ruchholtz; A Seekamp; H-C Pape; S Flohe; van M Griensven
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Trauma Department, Hannover Medical School, Germany; 2Trauma Department, University of Schleswig-Holstein, Kiel, Germany; 3Trauma Department, University of Marburg-Giessen, Germany; 4Trauma Department, University of Aachen, Germany; 5Trauma Department, University of Duesseldorf, Germany; 6Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria; 7Department of Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
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