| A Combined Trauma Model of Chest and Abdominal Trauma With Hemorrhagic Shock - Description of a new Porcine Model. | |
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MedLine Citation:
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PMID: 23042201 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Despite the high incidence and prognostic relevance of hemorrhagic shock, abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma model consisting of blunt chest trauma, penetrating abdominal trauma (two incisions in the right upper liver lobe using a four-edged scalpel and subsequent liver packing) and pressure-controlled hemorrhagic shock with a mean arterial pressure of 30 ± 5 mmHg (a maximum of 45% of the total blood volume). The combined traumatic insult led to severe signs of hemorrhagic shock and impaired pulmonary function.In conclusion, a consistent, reproducible and clinically relevant porcine model of multi-system injury with controlled (pressure-controlled blood withdrawal) and uncontrolled components of hemorrhage (liver laceration) with the potential for re-bleeding was established. |
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Authors:
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F Hildebrand; M Weuster; P Mommsen; J Mohr; M Fröhlich; I Witte; C Keibl; S Ruchholtz; A Seekamp; H-C Pape; S Flohe; van M Griensven |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-4 |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: - ISSN: 1540-0514 ISO Abbreviation: Shock Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Trauma Department, Hannover Medical School, Germany; 2Trauma Department, University of Schleswig-Holstein, Kiel, Germany; 3Trauma Department, University of Marburg-Giessen, Germany; 4Trauma Department, University of Aachen, Germany; 5Trauma Department, University of Duesseldorf, Germany; 6Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria; 7Department of Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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