| Combined SPECT and Multidetector CT for Prostate Cancer Evaluations. | |
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MedLine Citation:
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PMID: 22267999 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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(111)In-capromab pendetide is an imaging probe for noninvasive detection of prostate cancer dissemination, and can be difficult to interpret because of low photon statistics resulting in noisy images with limited anatomical precision. We examined if a 16-slice multidetector computed tomography (MDCT) combined with single photon emission computed tomography (SPECT) could increase the impact on the clinical management and improve confidence in SPECT image interpretations in comparison to a relatively low-mA (limited resolution) CT. 17 scans were reviewed from a SPECT combined with low-mA CT scanner; 21 scans were reviewed from a SPECT combined with 16-slice MDCT scanner. Reports of the clinical interpretations from the imaging studies, additional examinations performed by referring physicians as a follow-up to the imaging results, and long-term clinical and laboratory follow-ups were used to define confidence of the SPECT/CT readings and impact of the readings on the patient management. The impact was defined as: the occurrence of the (111)In-capromab pendetide interpretation resulted in additional imaging studies or biopsies. MDCT improved the quality and confidence in the characterization of small lymph nodes with or without uptake of (111)In-capromab pendetide. The increased confidence with MDCT in SPECT/CT readings was evident in all cases reviewed in this study, and the impact on the clinical management was higher (8 out of 21) using SPECT/MDCT than the impact using SPECT combined with low-mA CT (2 out of 17). The dual-modality SPECT/CT provides a quantifiable benefit when MDCT is used instead of low-mA CT, particularly for prostate cancer evaluations using (111)In-capromab pendetide. |
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Authors:
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Carina Mari Aparici; David Carlson; Nhan Nguyen; Randall A Hawkins; Youngho Seo |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: American journal of nuclear medicine and molecular imaging Volume: 2 ISSN: 2160-8407 ISO Abbreviation: - Publication Date: 2012 |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101564121 Medline TA: Am J Nucl Med Mol Imaging Country: - |
Other Details:
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Languages: ENG Pagination: 48-54 Citation Subset: - |
Affiliation:
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Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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K25 CA114254-05//NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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