Document Detail

Combined pulmonary fibrosis and emphysema alters physiology but has similar mortality to pulmonary fibrosis without emphysema.
MedLine Citation:
PMID:  20614219     Owner:  NLM     Status:  MEDLINE    
Studies have described individuals with combined pulmonary fibrosis and emphysema (CPFE), with preserved lung volumes, significant reductions in gas exchange, and high prevalence of pulmonary hypertension. While physiologic changes in CPFE are well documented, there is little mortality data in the CPFE population compared to appropriate controls. A study was performed to determine the features and outcomes of a group of individuals with imaging and/or pathologic evidence of CPFE to determine if individuals with combined pulmonary fibrosis and emphysema have different features and survival than individuals with pulmonary fibrosis alone. We conducted a retrospective study at a Veterans Affairs Medical Center. Included in the study were individuals hospitalized over a 5-year period who were given a clinical diagnosis of pulmonary fibrosis. Individuals with confirmed imaging or pathologic evidence of pulmonary fibrosis were divided into a study group with concomitant emphysema (CPFE group, n = 20) and a control group without emphysema (isolated pulmonary fibrosis (PF) group, n = 24). The CPFE group, all current or former cigarette smokers, had significantly larger lung volumes, more expiratory airflow obstruction, and worse gas exchange than the isolated pulmonary fibrosis group. Mortality did not differ between the groups. Combined pulmonary fibrosis and emphysema results in unique physiologic features but no difference in survival compared with a group with pulmonary fibrosis alone.
Matthew D Jankowich; Sharon Rounds
Related Documents :
8934399 - In vitro effect of meconium on the physical surface properties and morphology of exogen...
8523359 - Fatal pulmonary fibrosis complicating low dose methotrexate therapy for rheumatoid arth...
6716189 - Pulmonary function and respiratory symptoms in potash workers.
17195139 - High-resolution computed tomography of interstitial pulmonary fibrosis.
4025379 - Chronic interstitial pulmonary fibrosis following mycoplasma pneumoniae pneumonia.
1995219 - Changes in left ventricular diastolic filling patterns by doppler echocardiography in c...
20970639 - Posttransplantation portal thrombosis secondary to splenorenal shunt persistence.
21351229 - Myocardial infarction in a youngster due to giant coronary aneurysm.
10808149 - Invasive and non-invasive determinants of pulmonary hypertension in patients with chron...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-08
Journal Detail:
Title:  Lung     Volume:  188     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2011-01-10     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Asbestos / toxicity
Coronary Artery Disease / mortality
Diabetes Mellitus / mortality
Hypertension / mortality
Lung / physiopathology,  radiography
Middle Aged
Myocardial Infarction / mortality
Pulmonary Emphysema / mortality*,  physiopathology*,  radiography
Pulmonary Fibrosis / mortality*,  physiopathology*,  radiography
Retrospective Studies
Smoking / mortality
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cellular choreography in the germinal center: new visions from in vivo imaging.
Next Document:  Clusterin immunoexpression and its clinical significance in patients with non-small cell lung cancer...