Document Detail


Combined pulmonary fibrosis and emphysema alters physiology but has similar mortality to pulmonary fibrosis without emphysema.
MedLine Citation:
PMID:  20614219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies have described individuals with combined pulmonary fibrosis and emphysema (CPFE), with preserved lung volumes, significant reductions in gas exchange, and high prevalence of pulmonary hypertension. While physiologic changes in CPFE are well documented, there is little mortality data in the CPFE population compared to appropriate controls. A study was performed to determine the features and outcomes of a group of individuals with imaging and/or pathologic evidence of CPFE to determine if individuals with combined pulmonary fibrosis and emphysema have different features and survival than individuals with pulmonary fibrosis alone. We conducted a retrospective study at a Veterans Affairs Medical Center. Included in the study were individuals hospitalized over a 5-year period who were given a clinical diagnosis of pulmonary fibrosis. Individuals with confirmed imaging or pathologic evidence of pulmonary fibrosis were divided into a study group with concomitant emphysema (CPFE group, n = 20) and a control group without emphysema (isolated pulmonary fibrosis (PF) group, n = 24). The CPFE group, all current or former cigarette smokers, had significantly larger lung volumes, more expiratory airflow obstruction, and worse gas exchange than the isolated pulmonary fibrosis group. Mortality did not differ between the groups. Combined pulmonary fibrosis and emphysema results in unique physiologic features but no difference in survival compared with a group with pulmonary fibrosis alone.
Authors:
Matthew D Jankowich; Sharon Rounds
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-08
Journal Detail:
Title:  Lung     Volume:  188     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2011-01-10     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Asbestos / toxicity
Comorbidity
Coronary Artery Disease / mortality
Diabetes Mellitus / mortality
Humans
Hypertension / mortality
Lung / physiopathology,  radiography
Male
Middle Aged
Myocardial Infarction / mortality
Pulmonary Emphysema / mortality*,  physiopathology*,  radiography
Pulmonary Fibrosis / mortality*,  physiopathology*,  radiography
Retrospective Studies
Smoking / mortality
Grant Support
ID/Acronym/Agency:
HL 64936/HL/NHLBI NIH HHS; R01 HL064936/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
1332-21-4/Asbestos
Comments/Corrections

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