| Combined MR imaging and numerical simulation of flow in realistic arterial bypass graft models. | |
| | |
MedLine Citation:
|
PMID: 12122276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report methods for (a) transforming a three-dimensional geometry acquired by magnetic resonance angiography (MRA) in vivo, or by imaging a model cast, into a computational surface representation, (b) use of this to construct a three dimensional numerical grid for computational fluid dynamic (CFD) studies, and (c) use of the surface representation to produce a stereo-lithographic replica of the real detailed geometry, at a scale convenient for detailed magnetic resonance imaging (MRI) flow studies. This is applied to assess the local flow field in realistic geometry arterial bypass grafts. Results from a parallel numerical simulation and MRI measurement of flow in an aorto-coronary bypass graft with various inlet flow conditions demonstrate the strong influence of the graft inlet waveform on the perianastomotic flow field. A sinusoidal and a multi harmonic coronary flow waveform both with a mean Reynolds number (Re) of 100 and a Womersley parameter of 2.7 were applied at the graft inlet. A weak axial flow separation region just distal to the toe was found in sinusoidal flow near end deceleration (Re = 25). At the same location and approximately the same point in the cycle (Re = 30) but in coronary flow, the axial flow separation was stronger and more spatially pronounced. No axial flow separation occurred in steady flow for Re = 100. Numerical predictions indicate a region in the vicinity of the suture line (where there is a local narrowing of the graft) with a wall shear magnitude in excess of five times that associated with fully developed flow at the graft inlet. |
| | |
Authors:
|
Y Papaharilaou; D J Doorly; S J Sherwin; J Peiro; C Griffith; N Cheshire; V Zervas; J Anderson; B Sanghera; N Watkins; C G Caro |
Related Documents
:
|
1833406 - A new canine model for evaluating blood prosthetic arterial graft interactions. 11397026 - Harnessing haemodynamic forces for the suppression of anastomotic intimal hyperplasia: ... 17979876 - Tissue engineering of blood vessel. 9083846 - In-vivo measurements of blood flow velocity profiles in canine ilio-femoral anastomotic... 20164206 - Cholecystokinin as a regulator of cardiac function and postprandial gastrointestinal bl... 7814856 - Renovascular resistance in primary hypertension: experimental variations detected by me... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biorheology Volume: 39 ISSN: 0006-355X ISO Abbreviation: Biorheology Publication Date: 2002 |
Date Detail:
|
Created Date: 2002-07-17 Completed Date: 2002-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372526 Medline TA: Biorheology Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 525-31 Citation Subset: IM |
Affiliation:
|
Biomedical Flow Group, Aeronautics Department, Imperial College of Science, Technology and Medicine, Prince Consort Road, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Computer Simulation* Coronary Artery Bypass* Coronary Stenosis / physiopathology, surgery Coronary Vessels / physiopathology* Humans Magnetic Resonance Angiography* Models, Cardiovascular* Regional Blood Flow |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Atherosclerosis and flow in carotid arteries with authentic geometries.
Next Document: Disease patterns at arterial branches and their relation to flow.