| Combined Influence of Intermittent Exercise and Temperature Stress on the Modulation of Fluoride Toxicity. | |
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MedLine Citation:
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PMID: 22311083 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Regardless of the circumstantial evidences on the involvement of fluoride on the etiology and pathogenesis of fluorosis, several lines of evidences strongly indicate the influence of modulator factors such as duration of fluoride exposure, age, temperature, and physical activity. This study has been designed to investigate the combined influence of intermittent exercise and temperature stress on the modulation of fluoride toxicity. Three-month-old Wistar male rats were exposed to high sodium fluoride (600 ppm) through drinking water for 1 month and the rats were then subjected to swimming exercise at different temperatures (20°C, 25°C, 30°C, and 35°C). Oxidative stress indices analyzed showed fluoride-induced oxidative stress in biological tissues studied like brain, heart, liver, and kidney. Exercise regimen coupled with different temperatures were found to be effective in bringing the oxidative stress indices to near normal level indicating decreased free radical production which may be a compensatory mechanism to counteract against the detrimental effects of fluoride. Further, the deleterious effects of fluoride significantly reduced at 25°C and 30°C demonstrating that the thermoneutral temperatures were effective in reducing the toxicity level. |
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Authors:
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P Mahaboob Basha; N S Sujitha |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-5 |
Journal Detail:
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Title: Biological trace element research Volume: - ISSN: 1559-0720 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Bangalore University, Bangalore, Karnataka, India, pmbashabub@rediffmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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