Document Detail

Combined Doppler index to track instantaneous changes in left ventricular filling pressure.
MedLine Citation:
PMID:  16128376     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The ratio of early transmitral pulsed Doppler velocity (E) to colour M-mode Doppler flow propagation velocity (Vp) has been reported to be a good predictor of pulmonary capillary wedge pressure (PCWP) and left ventricular end-diastolic pressure (LVEDP). It is unknown whether E/Vp can be used to reflect the instantaneous haemodynamic change after drug intervention. METHODS AND RESULTS: The study population was composed of 19 patients who underwent elective cardiac catheterization for suspected coronary artery disease. Mean PCWP (mPCWP) obtained from right heart catheterization and LVEDP from a micromanometer-tipped catheter were compared with echocardiographic data before and 5 minutes after sublingual application of nitroglycerin (NTG) 0.6 mg. By stepwise multiple linear regression analysis, we found a positive correlation between mPCWP and E/Vp (beta, = 0.687, p = 0.001) and LVEDP and E/Vp (beta, = 0.718, p = 0.001). After NTG intake, the change in ENp was significantly correlated with the changes in mPCWP and LVEDP (r = 0.574, p = 0.010; r = 0.627, p = 0.004, respectively). CONCLUSIONS: In addition to being a useful predictor of mPCWP and LVEDP, the index, E/Vp, can be used to track the instantaneous changes in mPCWP and LVEDRP.
Ho-Ming Su; Tsung-Hsien Lin; Wen-Chol Voon; Wen-Ter Lai; Sheng-Hsiung Sheu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  60     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-30     Completed Date:  2006-02-16     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
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MeSH Terms
Blood Flow Velocity
Catheterization, Swan-Ganz
Coronary Artery Disease / diagnosis,  physiopathology*,  ultrasonography
Echocardiography, Doppler, Color / methods*
Linear Models
Middle Aged
Pulmonary Wedge Pressure / physiology*
Ventricular Function, Left / physiology*

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