Document Detail

Combined 595-nm and 1,064-nm laser irradiation of recalcitrant and hypertrophic port-wine stains in children and adults.
MedLine Citation:
PMID:  19397657     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Although pulsed dye laser (PDL) treatment of port-wine stain (PWS) has long been proven safe and effective, incomplete clearance of these vascular malformations can be problematic. In addition, advanced PWS with deeper coloration and tissue hypertrophy can be particularly difficult to treat because of the superficial dermal penetration of 585- to 595-nm light. The purpose of this study was to evaluate the safety and efficacy of a novel device that delivers sequential pulses of 595- and 1,064-nm wavelengths in the treatment of recalcitrant and hypertrophic PWS. METHODS: Twenty-five children and adults (skin phototypes I-III) with recalcitrant or hypertrophic PWS showing incomplete clearance after 10 prior PDL treatments were included in the study. Successive treatments using a 595-nm PDL and a 1,064-nm neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser were delivered at 6- to 8-week intervals. Two masked assessors determined clinical improvement of treatment areas using independent evaluation of comparative photographs at baseline and 3 months after treatment using a standard quartile grading scale. RESULTS: The use of dual 595-/1,064-nm wavelengths provided continued improvement of PWS that were previously recalcitrant to ongoing PDL therapy. Side effects were limited to transient erythema, edema, and mild purpura. Rare vesicle formation was observed, with no subsequent scarring or undesirable pigmentary changes. CONCLUSION: The novel dual 595-nm PDL and 1,064-nm Nd:YAG laser is an effective treatment for PWS that are recalcitrant to PDL therapy alone.
Tina S Alster; Elizabeth L Tanzi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-04-09
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  35     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  914-8; discussion 918-9     Citation Subset:  IM    
Washington Institute of Dermatologic Laser Surgery, Washington, District of Columbia, USA.
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MeSH Terms
Child, Preschool
Dose-Response Relationship, Radiation
Follow-Up Studies
Laser Therapy, Low-Level / instrumentation*
Lasers, Solid-State / therapeutic use*
Middle Aged
Port-Wine Stain / pathology,  radiotherapy*
Severity of Illness Index
Skin / pathology*
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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