| Combined 1H and 31P NMR studies of cerebral metabolism in vivo. | |
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MedLine Citation:
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PMID: 3577213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NMR spectroscopic methods have recently been developed for measurement of several concentrated cerebral metabolites in vivo. At present, 31P spectra from the brain permit detection of ATP, PCr, Pi, and certain sugar and lipid phosphates. The resonant frequency of Pi also provides a measure of cerebral pHi, and under some conditions ADP concentration can be calculated from information available in the 31P spectrum. The 1H spectrum of brain provides measurements of lactate, creatine, and several amino acids and choline-containing compounds. Both kinds of spectra can be obtained from the same subject. Our group at Yale used combined 31P and 1H methods to demonstrate that loss and recovery of phosphate energy stores and concomitant changes in cerebral amino acids during hypoglycemic coma in rodents could be observed in vivo. We then used the same methods to show that cerebral pHi can be normal while lactate is elevated in status epilepticus. NMR spectroscopy performed in vivo provides an array of chemically specific measurements unavailable by any other non-invasive method. It is thought to be entirely free of deleterious biological effects; hence, its potential for use in humans is considerable. |
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Authors:
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J W Prichard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Yale journal of biology and medicine Volume: 60 ISSN: 0044-0086 ISO Abbreviation: Yale J Biol Med Publication Date: 1987 Mar-Apr |
Date Detail:
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Created Date: 1987-05-27 Completed Date: 1987-05-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417414 Medline TA: Yale J Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-7 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Energy Metabolism Hydrogen-Ion Concentration Lactates / metabolism Magnetic Resonance Spectroscopy / methods* Phosphates / metabolism Rats |
| Grant Support | |
ID/Acronym/Agency:
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GM 30287/GM/NIGMS NIH HHS; NS 21708/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Phosphates |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Yale J Biol Med Journal ID (pmc): yjbm ISSN: 0044-0086 ISSN: 1551-4056 Publisher: Yale Journal of Biology and Medicine |
Article Information Download PDF  Print publication date: Season: Mar–Apr Year: 1987 Volume: 60 Issue: 2 First Page: 151 Last Page: 157 ID: 2590310 PubMed Id: 3577213 |
| Combined 1H and 31P NMR studies of cerebral metabolism in vivo. | |
| J. W. Prichard | |
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