| Combined 18F-FDG PET/CT Imaging for the Initial Evaluation of Glottic Cancer. | |
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MedLine Citation:
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PMID: 19434260 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: The primary aim of this study was to determine whether 18F-FDG-PET/CT (PET/CT) scans provide additional diagnostic information in addition to the direct laryngoscopic examination (L/E) and contrast-enhanced CT (CT) in patients with glottic cancer during the initial evaluation. METHODS: Fifty-five consecutive patients with glottic cancer of the larynx that had L/E, CT and PET/CT were enrolled. The diagnostic value of each modality was compared for their accuracy in predicting the extent of the primary tumors on sub-site based analysis and the final tumor staging. The reference standards were either the surgical pathology findings or clinical/radiological follow-up outcome. Changes in patient care based on PET/CT results were compared with the treatment decisions based on L/E with CT. RESULTS: For primary tumor sub-site based analysis, the sensitivity was significantly higher for L/E (92.8%) than for PET/CT (79.4%, P=0.028). The comparisons between L/E vs. CT and CT vs. PET/CT did not reach statistical significance. As an initial tumor-staging method the L/E had a diagnostic accuracy of 76.4%, compared to 61.8% for CT and 41.8% for PET/CT. The L/E and CT were better than the PET/CT (P=0.0009 and 0.049) for the initial TNM staging. PET/CT scanning changed the clinical decision-making based on the L/E with CT results in 12.7% of cases, of whom 5.5% had no additional PET/CT related benefit. CONCLUSION: The results of this study showed that PET/CT imaging added no clinical information benefit compared to the L/E and CT for the initial evaluation of patients with glottic cancer. |
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Authors:
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Han-Sin Jeong; Man Ki Chung; Chung-Hwan Baek; Joon Young Choi; Young-Ik Son; Hyung-Jin Kim; Sang Duk Hong; Kwon Hyo Bok |
Publication Detail:
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Type: Journal Article Date: 2008-03-20 |
Journal Detail:
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Title: Clinical and experimental otorhinolaryngology Volume: 1 ISSN: 1976-8710 ISO Abbreviation: Clin Exp Otorhinolaryngol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2009-05-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474010 Medline TA: Clin Exp Otorhinolaryngol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 35-40 Citation Subset: - |
Affiliation:
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Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
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