| Combinatorial regulation of tissue specification by GATA and FOG factors. | |
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MedLine Citation:
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PMID: 23048181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of complex organisms requires the formation of diverse cell types from common stem and progenitor cells. GATA family transcriptional regulators and their dedicated co-factors, termed Friend of GATA (FOG) proteins, control cell fate and differentiation in multiple tissue types from Drosophila to man. FOGs can both facilitate and antagonize GATA factor transcriptional regulation depending on the factor, cell, and even the specific gene target. In this review, we highlight recent studies that have elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use these diverse modes of gene regulation to control cell lineage specification throughout metazoans. |
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Authors:
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Timothy M Chlon; John D Crispino |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: 2012-12-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 3905-16 Citation Subset: IM |
Affiliation:
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Department of Medicine, Northwestern University, Chicago, IL 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals GATA Transcription Factors / genetics, metabolism* Gene Expression Regulation, Developmental Humans Nuclear Proteins / genetics, metabolism* Transcription Factors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/GATA Transcription Factors; 0/Nuclear Proteins; 0/Transcription Factors; 0/ZFPM1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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