Document Detail

Combinatorial regulation of tissue specification by GATA and FOG factors.
MedLine Citation:
PMID:  23048181     Owner:  NLM     Status:  MEDLINE    
The development of complex organisms requires the formation of diverse cell types from common stem and progenitor cells. GATA family transcriptional regulators and their dedicated co-factors, termed Friend of GATA (FOG) proteins, control cell fate and differentiation in multiple tissue types from Drosophila to man. FOGs can both facilitate and antagonize GATA factor transcriptional regulation depending on the factor, cell, and even the specific gene target. In this review, we highlight recent studies that have elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use these diverse modes of gene regulation to control cell lineage specification throughout metazoans.
Timothy M Chlon; John D Crispino
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2012-12-20     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3905-16     Citation Subset:  IM    
Department of Medicine, Northwestern University, Chicago, IL 60611, USA.
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MeSH Terms
GATA Transcription Factors / genetics,  metabolism*
Gene Expression Regulation, Developmental
Nuclear Proteins / genetics,  metabolism*
Transcription Factors / genetics,  metabolism*
Reg. No./Substance:
0/GATA Transcription Factors; 0/Nuclear Proteins; 0/Transcription Factors; 0/ZFPM1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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