Document Detail

Combinatorial control of cell fate and reprogramming in the mammalian germline.
MedLine Citation:
PMID:  22795169     Owner:  NLM     Status:  MEDLINE    
Development of mammalian primordial germ cells (PGCs) presents a unique example of a cell fate specification event that is intimately linked with epigenetic reprogramming. Cell fate commitment is governed by transcription factors which, together with epigenetic regulators, instruct lineage choice in response to signalling cues. Similarly, the reversal of epigenetic silencing is driven by the combinatorial action of transcriptional regulators, resulting in an increase in cellular plasticity. PGCs constitute a paradox, since their development as a unipotent specialised lineage is coupled with extensive reprogramming, which eventually leads to an increase in cellular potency. In this review we discuss the role of key factors in the specification of the germ cell lineage that are also important for the comprehensive erasure of epigenetic modifications, which provides the foundation for regeneration of totipotency. We further discuss current concepts of transcriptional and epigenetic control of cell fate decisions, with a particular focus on emerging principles of enhancer activity and their potential implications for the transcriptional control of PGC specification.
Erna Magnúsdóttir; Astrid Gillich; Nils Grabole; M Azim Surani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-12
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  22     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-04-04     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  466-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Cell Differentiation*
Cell Lineage
DNA Methylation
Embryonic Stem Cells / cytology*,  metabolism
Epigenesis, Genetic
Gene Silencing
Germ Cells / metabolism*
Nuclear Reprogramming*
Signal Transduction
Transcription Factors
Grant Support
079249//Wellcome Trust; 092096//Wellcome Trust; G0800784//Medical Research Council; RG44593//Wellcome Trust
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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