Document Detail

Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor.
MedLine Citation:
PMID:  7514858     Owner:  NLM     Status:  MEDLINE    
Combinations of the human immunodeficiency virus (HIV) Tat protein antagonist Ro 24-7429 with either the HIV protease inhibitor Ro 31-8959 or the HIV reverse transcriptase inhibitors AZT (3'-azido-3'-deoxythymidine), ddC (2',3'-dideoxycytidine), ddI (2',3'-dideoxyinosine), and nevirapine were synergistic or additive in reducing HIV type 1 p24 antigen production in CEM cells or inhibiting HIV type 1-induced syncytium formation in HT4-6C cells.
E V Connell; M C Hsu; D D Richman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  38     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-22     Completed Date:  1994-06-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  348-52     Citation Subset:  IM; X    
Department of Virology, Hoffmann-LaRoche Inc., Nutley, New Jersey 07110.
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MeSH Terms
Antiviral Agents / pharmacology*
Benzodiazepines / pharmacology*
Didanosine / pharmacology
Drug Synergism
Gene Products, tat / antagonists & inhibitors*
HIV / drug effects,  enzymology
HIV Protease Inhibitors / pharmacology*
Hela Cells
Isoquinolines / pharmacology*
Pyridines / pharmacology
Quinolines / pharmacology*
Reverse Transcriptase Inhibitors*
Zalcitabine / pharmacology
Zidovudine / pharmacology
tat Gene Products, Human Immunodeficiency Virus
Grant Support
Reg. No./Substance:
0/Antiviral Agents; 0/Gene Products, tat; 0/HIV Protease Inhibitors; 0/Isoquinolines; 0/Pyridines; 0/Pyrroles; 0/Quinolines; 0/Reverse Transcriptase Inhibitors; 0/tat Gene Products, Human Immunodeficiency Virus; 127779-20-8/Saquinavir; 12794-10-4/Benzodiazepines; 129618-40-2/Nevirapine; 139339-45-0/Ro 24-7429; 30516-87-1/Zidovudine; 69655-05-6/Didanosine; 7481-89-2/Zalcitabine

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