Document Detail


Combinative improving effect of increased solubility and the use of absorption enhancers on the rectal absorption of uracil in beagle dogs.
MedLine Citation:
PMID:  2285989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An improvement of the rectal absorption of uracil was examined by the application of absorption enhancers in addition to the increased solubility of uracil. Uracil was ground with additives such as MgO, sodium 2,6-dihydroxybenzoate, human serum albumin or hydroxypropylmethylcellulose acetate succinate. Aqueous, oily and powdery formulations, which consisted of the ground mixtures, nicotinamide, urea and absorption enhancers such as polyoxyethylene (23) cetylether (BC-23) or sodium caprate, were prepared. Uracil solubility in the aqueous formulations was increased about 4-13 times that in the corresponding control formulations. When rectally administered to beagle dogs, marked increases in the plasma uracil level were observed in some of the cases of aqueous and oily formulations. In the powdery formulations and formulations containing macromolecular additives, however, absorption improvements was not observed. The results indicated that an improvement in the absorption of uracil was caused by the combinative improving effect of the increased uracil solubility and the promoting effect of absorption enhancers.
Authors:
Y Takeichi; K Baba; Y Kinouchi; Y Iida; Y Umeno; S Muranishi; Y Nakai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  38     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-03-25     Completed Date:  1991-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  2547-51     Citation Subset:  IM    
Affiliation:
Pharmaceutical Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Absorption / drug effects
Animals
Chemistry, Pharmaceutical
Dogs
Drug Synergism
Humans
Male
Rectum / metabolism*
Solutions
Uracil / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Solutions; 66-22-8/Uracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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