Document Detail

Combinations of potassium, calcium, and magnesium supplements in hypertension.
MedLine Citation:
PMID:  7490154     Owner:  NLM     Status:  MEDLINE    
Dietary intakes of potassium, calcium, and magnesium have each been reported to lower blood pressure, but the extent of blood pressure reduction in epidemiological studies and clinical trials has tended to be small and inconsistent. We hypothesized that combinations of these mineral supplements would lower blood pressure and that the reductions would be greater than that usually reported in studies of each cation alone. One hundred twenty-five patients 82 men and 43 women) with untreated mild or borderline hypertension were randomly assigned to daily treatment with one of the following four regimens: 60 mmol potassium and 25 mmol (1000 mg) calcium, 60 mmol potassium and 15 mmol (360 mg) magnesium, calcium and magnesium, or placebo. Standardized clinic blood pressure measurements were obtained on 3 days at baseline and after 3 and 6 months of treatment. At baseline, systolic and diastolic blood pressures (mean +/- SD) were 139 +/- 12 and 90 +/- 4 mm Hg, respectively, and dietary intakes of potassium, calcium, and magnesium were 77 +/- 32, 19 +/- 13, and 12 +/- 52 mmol/d, respectively. The mean differences (with 95% confidence intervals) of the changes in systolic and diastolic blood pressures between the treatment and placebo groups were not significant: -0.7 (-4.3 to +2.9) and -0.4 (-2.9 to +2.1) for potassium and calcium, -1.3 (-4.4 to +1.8) and 0.4 (-2.5 to +3.3) for potassium and magnesium, and +2.1 (-1.8 to +6.0) and +2.2 (-1.0 to +5.4) for calcium and magnesium. In conclusion, this trial provides little evidence of an important role of combinations of cation supplements in the treatment of mild or borderline hypertension.
F M Sacks; L E Brown; L Appel; N O Borhani; D Evans; P Whelton
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  26     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  950-6     Citation Subset:  IM    
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Mass, USA.
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MeSH Terms
Blood Pressure
Calcium / administration & dosage,  therapeutic use*
Calcium Carbonate / administration & dosage,  therapeutic use
Confidence Intervals
Drug Therapy, Combination
Follow-Up Studies
Food, Fortified*
Hypertension / drug therapy*,  physiopathology
Magnesium / administration & dosage,  therapeutic use*
Middle Aged
Potassium / administration & dosage,  therapeutic use*
Potassium Chloride / administration & dosage,  therapeutic use
Time Factors
Grant Support
Reg. No./Substance:
0/Placebos; 471-34-1/Calcium Carbonate; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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