Document Detail

Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer's disease.
MedLine Citation:
PMID:  19300399     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer's disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patients mainly in frontal and temporal lobes. In both groups no correlation was found between FA and age or MMSE. Patients with AD showed a significant decrease in FA and an increase in mean diffusivity (p<0.0001) in the corpus callosum. CONCLUSIONS: In patients with AD we observed a significant reduction in FA values and GM volume; however, no correlation with age and MMSE was proven for both FA and GM for AD patients. This finding supports the hypothesis that morphological changes in patients with AD are not a continuous aging related process but represent qualitative changes.
Ibrahim Ibrahim; Jiri Horacek; Ales Bartos; Milan Hajek; Daniela Ripova; Martin Brunovsky; Jaroslav Tintera
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  30     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-14     Completed Date:  2009-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, MR Unit, Prague, Czech Republic.
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MeSH Terms
Age Factors
Aged, 80 and over
Alzheimer Disease / diagnosis*
Corpus Callosum / pathology,  radiography
Diffusion Magnetic Resonance Imaging / methods*
Echo-Planar Imaging / methods*
Middle Aged
Organ Size
Psychological Tests

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