| Combination of uterine artery Doppler velocimetry and maternal serum placental growth factor estimation in predicting occurrence of pre-eclampsia in early second trimester pregnancy: a prospective cohort study. | |
| | |
MedLine Citation:
|
PMID: 22280827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the effectiveness of the combined use of uterine artery Doppler velocimetry (UADV) and estimation of maternal serum placental growth factor (PlGF) levels in early second trimester (20-22 weeks of gestation) in identifying pregnant women at risk of developing pre-eclampsia. STUDY DESIGN: Prospective cohort study on 1104 pregnant women with singleton pregnancies between May 2009 and December 2010. UADV and maternal serum PlGF estimation were done at 20-22 weeks' gestation. Association between the two variables and the occurrence of pre-eclampsia was analyzed by logistic regression analysis and odds ratio was computed. The results were considered significant when p was <0.05. RESULTS: Logistic regression analysis showed that both abnormal UADV (odds ratio (OR) 4.1; 95% CI 2.3-7.2; p=0.000) and serum PlGF<188pg/ml (OR 3.6; 95% CI 1.95-6.5; p=0.000) are independent variables in the occurrence of pre-eclampsia, and the difference between the association of these two variables with pre-eclampsia was statistically insignificant as 95% CI values overlap. Multivariate logistic regression analysis showed that a combination of abnormal UADV and serum PlGF<188pg/ml at 20-22 weeks had a very poor association (OR 1.1; 95% CI 0.3-3.8; p=0.938) with the occurrence of pre-eclampsia, as the 95% CI values encompass 1 and p is >0.05. CONCLUSION: UADV and maternal serum PlGF estimation at 20-22 weeks of gestation are strong predictors of the occurrence of pre-eclampsia when used individually but in combination their association with pre-eclampsia is not significant. |
| | |
Authors:
|
Sanjib Kumar Ghosh; Shashi Raheja; Anita Tuli; Chitra Raghunandan; Sneh Agarwal |
Related Documents
:
|
22344967 - Pregnancy outcomes in liver transplant recipients: a systematic review and meta-analysis. 20025637 - Cerebral venous sinus thrombosis in early pregnancy: an unusual presentation of primary... 21718257 - Older mothers do not confer greater perinatal risk to dichorionic diamniotic twins. 9307857 - A prospective study of fifty-three consecutive calcium heparin treated pregnancies in p... 19399757 - Reference values for gamma-glutamyl-transferase in amniotic fluid in normal pregnancies. 12677617 - Distance to the adult cervical epidural space. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: - ISSN: 1872-7654 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Anatomy, Lady Hardinge Medical College & Smt. Sucheta Kriplani Hospital, Shaheed Bhagat Singh Marg, New Delhi 110001, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Positive reproductive family history for spontaneous abortion: predictor for recurrent miscarriage i...
Next Document: Oxygen Therapy Multicentric Study - A Nationwide Audit to Oxygen Therapy Procedures in Internal Medi...