| Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection. | |
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MedLine Citation:
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PMID: 9134874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In infants and children with maternally acquired human immunodeficiency virus type 1 (HIV-1) infection, treatment with a single antiretroviral agent has limited efficacy. We evaluated the safety and efficacy of a three-drug regimen in a small group of maternally infected infants. METHODS: Zidovudine, didanosine, and nevirapine were administered in combination orally to eight infants 2 to 16 months of age. The efficacy of antiretroviral treatment was evaluated by serial measurements of plasma HIV-1 RNA, quantitative plasma cultures, and quantitative cultures of peripheral-blood mononuclear cells. RESULTS: The three-drug regimen was well tolerated, without clinically important adverse events. Within four weeks, there were reductions in plasma levels of HIV-1 RNA of at least 96 percent (1.5 log) in seven of the eight study patients. Over the 6-month study period, replication of HIV-1 was controlled in two infants who began therapy at 2 1/2 months of age. Plasma RNA levels were reduced by 0.5 to 1.5 log in five of the other six infants. CONCLUSIONS: Although further observations are needed, it appears that in infants with maternally acquired HIV-1 infection, combined treatment with zidovudine, didanosine, and nevirapine is well tolerated and has sustained efficacy against HIV-1. |
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Authors:
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K Luzuriaga; Y Bryson; P Krogstad; J Robinson; B Stechenberg; M Lamson; S Cort; J L Sullivan |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 336 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-05-08 Completed Date: 1997-05-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1343-9 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Pediatrics, University of Massachusetts Medical School, Worcester 01605, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anti-HIV Agents / blood, therapeutic use* CD4 Lymphocyte Count / drug effects Didanosine / therapeutic use* Drug Therapy, Combination Female HIV Infections / drug therapy*, immunology, virology HIV-1* / drug effects, isolation & purification Humans Infant Infectious Disease Transmission, Vertical Male Nevirapine Pyridines / blood, therapeutic use* RNA, Viral / blood Viral Load Zidovudine / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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AI27550/AI/NIAID NIH HHS; AI30629/AI/NIAID NIH HHS; AI32907/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Pyridines; 0/RNA, Viral; 129618-40-2/Nevirapine; 30516-87-1/Zidovudine; 69655-05-6/Didanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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