Document Detail

Combination treatment with etanercept and an intensive spa rehabilitation program in active ankylosing spondylitis.
MedLine Citation:
PMID:  20074478     Owner:  NLM     Status:  MEDLINE    
The aim of this study is to determine the effects of a combination treatment with etanercept and spa rehabilitation versus etanercept alone on function, disability and quality of life in a group of patients with active ankylosing spondylitis (AS). Sixty patients with AS underwent etanercept as suggested by ASAS/EULAR recommendations. As the clinical and laboratory conditions improved, 30 patients accepted the proposal of coupling the medical therapy with a 7-day rehabilitation program in a thermal baths centre; the remaining 30 subjects continued to take the biologic agent alone. The comparisons between the 2 groups were made after 3 and 6 months. The primary outcome was an improvement in BASFI. The secondary outcome was an improvement in the visual analogic scale of EuroQol (EQ-5Dvas). After 6 months a statistically significant improvement in BASFI (p < 0.05) and EQ-5DVAS (p < 0.05) scores was observed in both groups. The mean change in EQ-5DVAS value showed a statistically significant difference in favour of the combination therapy group versus the monotherapy group (22 vs 32, p < 0.05). A therapeutic regimen combining etanercept with an intensive rehabilitation program contributes to disability reduction and ameliorates quality of life for AS patients.
M Colina; G Ciancio; R Garavini; M Conti; F Trotta; M Govoni
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  22     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2009 Oct-Dec
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1125-9     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Combined Modality Therapy
Disability Evaluation
Immunoglobulin G / therapeutic use*
Middle Aged
Quality of Life
Receptors, Tumor Necrosis Factor / therapeutic use*
Recovery of Function
Spondylitis, Ankylosing / drug therapy*,  physiopathology,  rehabilitation*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 185243-69-0/TNFR-Fc fusion protein

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