| Combination treatment in CTCL: the current role of bexarotene. | |
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MedLine Citation:
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PMID: 23149703 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Primary cutaneous T-cell lymphomas are a heterogeneous group of extranodal NH lymphomas primarily presenting in the skin without extracutaneos involvement at diagnosis. Treatment choices closely depend on clinic-pathologic entity and disease stage. Among available choices, oral bexarotene has shown efficacy and safety both in monotherapy and in association with other treatments, by virtue of its versatility and high synergism with alpha-interferon, photochemotherapy (PUVA), and chemotherapy. Moreover, when associated with a wise management of its side effects, bexarotene is well tolerated if used in long-term administration, and it is therefore a good candidate to maintenance treatment after different induction therapies. Recently, the Gruppo Italiano Linfomi Cutanei (GILC) has started some pilot studies, with the aim to investigate bexarotene potential in association with PUVA and single agent chemotherapy (as pegylated liposomal doxorubicin and gemcitabine), and as consolidation/maintenance treatment. The preliminary results of GILC pilot studies confirm the good tolerability and safety of low-intermediate dose bexarotene, and its potential synergism with PUVA and chemotherapy. In addition, its use in consolidation/maintenance has proven efficacy in improving overall response rate. |
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Authors:
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C Delfino; V Grandi; A Pileri; S Rupoli; P Quaglino; R Alterini; G Goteri; L Canafoglia; N Pimpinelli |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia Volume: 147 ISSN: 0392-0488 ISO Abbreviation: G Ital Dermatol Venereol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102852 Medline TA: G Ital Dermatol Venereol Country: - |
Other Details:
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Languages: ENG Pagination: 573-580 Citation Subset: - |
Affiliation:
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Division of Dermatology, Department of Critical Care Medicine and Surgery - nicola.pimpinelli@unifi.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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