Document Detail

Combination thrombolytic and anticoagulant therapy for bilateral renal vein thrombosis in a premature infant.
MedLine Citation:
PMID:  11552182     Owner:  NLM     Status:  MEDLINE    
We report a premature infant with bilateral renal vein thrombosis and renal failure at 1 month of age who underwent treatment with recombinant tissue plasminogen activator and heparin sulfate. Combination thrombolytic and anticoagulation therapy was complicated by an intraventricular and intraparenchymal cerebral hemorrhage without resolution of the renal vein thrombosis. With increasing reports of successful use of this therapy for venous thrombosis, we suggest caution and continued study of its use in the premature infant and newborn.
N Weinschenk; M Pelidis; J Fiascone
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  18     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-11     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-7     Citation Subset:  IM    
Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts, USA.
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MeSH Terms
Anticoagulants / therapeutic use*
Fibrinolytic Agents / therapeutic use
Heparin / therapeutic use
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Recombinant Proteins / therapeutic use
Renal Artery Obstruction / drug therapy*
Thrombolytic Therapy*
Thrombosis / drug therapy*
Tissue Plasminogen Activator / therapeutic use*
Reg. No./Substance:
0/Anticoagulants; 0/Fibrinolytic Agents; 0/Recombinant Proteins; 9005-49-6/Heparin; EC Plasminogen Activator

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