Document Detail


Combination therapy with ranitidine and pirenzepine for control of intragastric pH in the critically ill.
MedLine Citation:
PMID:  3839449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a prospective study of pH control for stress ulcer prophylaxis, intermittent iv infusion of the anticholinergic drug pirenzepine maintained the intragastric pH above 4 in only one of 17 ICU patients, while similar administration of the H2-receptor antagonist ranitidine was successful in seven of 32 patients. This difference was not statistically significant. Of 15 patients in whom a maximum dose of 600 mg/day of ranitidine or 90 mg/day of pirenzepine failed to maintain pH, combination therapy was successful in 11, a significant (p less than .01) improvement. We conclude that neither ranitidine nor pirenzepine provides adequate control of pH for stress ulcer prophylaxis when used alone. If used together they are the most effective combination so far described for parenteral control of gastric pH in the critically ill. Regular monitoring of gastric pH is nevertheless essential to allow detection of therapeutic failures.
Authors:
D G More; R F Raper; C J Watson; G M Shenfield
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  13     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-08-30     Completed Date:  1985-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Benzodiazepinones / administration & dosage,  therapeutic use*
Critical Care*
Drug Evaluation
Drug Therapy, Combination
Female
Gastric Acidity Determination
Humans
Hydrogen-Ion Concentration
Infusions, Parenteral
Intensive Care Units
Male
Middle Aged
Peptic Ulcer / prevention & control*
Pirenzepine
Prospective Studies
Random Allocation
Ranitidine / administration & dosage,  therapeutic use*
Risk
Stress, Physiological*
Chemical
Reg. No./Substance:
0/Benzodiazepinones; 28797-61-7/Pirenzepine; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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