| Combination therapy with mucosal protective agent for the eradication of Helicobacter pylori. | |
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MedLine Citation:
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PMID: 8574735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effect of plaunotol in combination with proton-pump inhibitors on Helicobacter pylori eradication in patients with gastric ulcer. PATIENTS AND METHODS: We studied 65 H. pylori-positive gastric ulcer patients. They were randomly assigned to five treatment groups: omeprazole (group I, n = 8), lansoprazole (group II, n = 13), lansoprazole+plaunotol (group III, n = 12), lansoprazole+clarithromycin (group IV, n = 16) and lansoprazole+plaunotol+clarithromycin (group V, n = 16). Ulcer status was diagnosed by endoscopy and H. pylori status by culture, histology, a urease test and a urea breath test at baseline, and after 8 and 12 weeks. The clearance and eradication rates were compared in each group. RESULTS: The healing rates in groups I-V were 100, 92, 100, 100 and 100%, respectively; clearance rates were 0, 23, 42, 50 and 75%, respectively; and eradication rates were 0, 0, 8, 38 and 69%, respectively. CONCLUSION: Combination therapy with plaunotol is efficacious for the eradication of H. pylori in gastric ulcer patients. |
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Authors:
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Y Fukuda; I Yamamoto; M Okui; Y Tonokatsu; K Tamura; T Shimoyama |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 7 Suppl 1 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-03-13 Completed Date: 1996-03-13 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S45-7 Citation Subset: IM |
Affiliation:
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Fourth Department of Internal Medicine, Hyogo College of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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administration & dosage,
therapeutic use Anti-Ulcer Agents / administration & dosage, therapeutic use* Biopsy Clarithromycin / administration & dosage, therapeutic use Colony Count, Microbial Drug Therapy, Combination Fatty Alcohols / administration & dosage, therapeutic use* Gastric Mucosa / drug effects*, microbiology Gastroscopy Helicobacter Infections / complications, drug therapy*, microbiology Helicobacter pylori / drug effects, isolation & purification* Humans Stomach Ulcer / drug therapy*, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Fatty Alcohols; 64218-02-6/plaunotol; 81103-11-9/Clarithromycin |
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