Document Detail

Combination therapy with felodipine and metoprolol compared with captopril and hydrochlorothiazide. German MC Study Group.
MedLine Citation:
PMID:  10321444     Owner:  NLM     Status:  MEDLINE    
This study compared the antihypertensive efficacy and tolerability of a combination tablet containing the vascular-selective calcium antagonist felodipine and the beta1-selective adrenergic antagonist metoprolol, with a combination tablet of captopril-hydrochlorothiazide in a randomized, double-blind trial involving 109 patients with mild to moderate hypertension. After 2 weeks on placebo, patients with a supine diastolic blood pressure of 95-115 mm Hg were randomized to felodipine-metoprolol, 5/50 mg o.d. (Logimax) or captopril-hydrochlorothiazide, 25/25 mg o.d. (Capozide). After a further 4 weeks, there was a mandatory dose increase to felodipine-metoprolol 10/100 mg o.d., and captopril-hydrochlorothiazide, 50/25 mg o.d., and treatment then continued for a another 4 weeks. At the end of the study, felodipine-metoprolol reduced supine blood pressure significantly more than captopril-hydrochlorothiazide. The mean differences in change in supine systolic and diastolic blood pressure between treatments after 8 weeks were 5.2 and 3.4 mm Hg, respectively, in favour of felodipine-metoprolol (p<0.05). Standing blood pressure also showed trends in favour of felodipine-metoprolol. The proportion of responders was similar in both groups. Both treatments were well tolerated. Two patients treated with felodipine-metoprolol and 5 with captopril-hydrochlorothiazide discontinued treatment due to adverse events. Felodipine-metoprolol combination reduced supine blood pressure significantly more than captopril-hydrochlorothiazide with maintained tolerability.
G Klein
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Blood pressure     Volume:  7     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-07-02     Completed Date:  1999-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  308-12     Citation Subset:  IM    
Klinik Höhenried für Herz- und Kreislauferkrankungen, Germany.
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MeSH Terms
Antihypertensive Agents / adverse effects,  therapeutic use*
Calcium Channel Blockers / adverse effects,  therapeutic use*
Captopril / adverse effects,  therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Felodipine / adverse effects,  therapeutic use*
Hydrochlorothiazide / adverse effects,  therapeutic use*
Hypertension / drug therapy*
Metoprolol / adverse effects,  therapeutic use*
Middle Aged
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 37350-58-6/Metoprolol; 58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril; 72509-76-3/Felodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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